Chlorogenic acid, an antioxidant principle from the aerial parts ofArtemisia iwayomogi that acts on 1,1-diphenyl-2-picrylhydrazyl radical |
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Authors: | Soon Shin Kim Chung Kyu Lee Sam Sik Kang Hyun Ah Jung Jae Sue Choi |
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Affiliation: | (1) College of Pharmacy, Kyungsung University, 608-736 Pusan, Korea;(2) Natural Products Research Institute, Seoul National University, 110-460, Korea;(3) Department of Food and Life Science, Pukyong National University, 608-737 Pusan, Korea |
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Abstract: | The antioxidant activity ofArtemisia iwayomogi was determined by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical The methanol extract ofA. iwayomogi showed strong antioxidant activity, and thus fractionated with several solvents. The antioxidant activity potential of the individual fraction was in the order of ethyl acetate>n-butanol>water>chloroform>n-hexane fraction. The ethyl acetate andn-butanol soluble fractions exhibiting strong antioxidant activity were further purified by repeated silica gel and Sephadex LH-20 column chromatography. Antioxidant chlorogenic acid was isolated as one of the active principles from then-butanol fraction, together with the inactive components, 1-octacosanol, scopoletin, scopolin, apigenin 7,4′-di-O-methylether luteolin 6,3′-di-O-methylether (jaceosidin), apigenin 7-methylether (genkwanin), 2,4-dihydroxy-6-methoxyacetophenone 4-O-β-D-glucopyranoside and quebrachitol. The antioxidant activity of chlorogenic acid was comparable to that of L-ascorbic acid, which is a well known antioxidant. |
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Keywords: | Artemisia iwayomogi chlorogenic acid antioxidant activity 1-octacosanol apigenin 7,4′ -di-O-methylether jaceosidin genkwanin 2,4-dihydroxy-6-methoxyacetophenone 4-O-β -D-glucopyranoside |
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