MnDPDP的MR增强扫描在肝脏病变中的应用

目的: 评价与探讨MnDPDP增强MR扫描在肝脏病变中的影像表现及诊断价值. 方法: 收集肝脏病变患者13人,其中11例经手术或病理活检证实,2例经影像为主的综合检查证实,均行T1WI及T2WI扫描(T1-FFE, T1-TFE, T2-TSE序列),注入0.5 mL/kg MnDPDP后20 min及24 h分别行T1WI扫描. 结果: 6例肝细胞型肝癌于MnDPDP增强后表现为不同程度的强化,1例FNH及1例肝腺瘤无明显强化或轻度均匀一致强化,2例肝血管瘤及3例肝转移瘤无强化,但3例转移瘤24 h延迟后可见周围肝组织内环形强化,并于24 h后发现更多小病灶. 结论: MnDPDP作为一种新型的MR对比剂,对肝脏病变的检测和诊断具有较大的临床价值.

MnDPDP enhanced magnetic resonance imaging of focal liver lesion

AIM: To study the MnDPDP enhanced magnetic resonance imagings and to assess their diagnostic value in MR examination. METHODS: Thirteen patients with hepatic lesions were included in this study, 11 cases of which had been confirmed by either operation or biopsy. T 1WI (T 1 FFE, T 1 TFE ) and T 2WI (T 2 TSE) were performed prior to the administration of contrast agent. T1 weighted images were then obtained at 20 min and 24 h following intravenous infusion of 0.5 mL/kg MnDPDP. RESULTS: Six cases of hepetocellular carcinoma showed detectable enhancement with MnDPDP, varying patterns of enhancement were obtained. In 1 case of focal nodular hyperplasia (FNH) and 1 case of hepatocellular adenoma, lesions appeared iso intense or hyper intense compared with normal liver in early phase imaging. In 2 cases of liver haemangioma and 3 cases of liver metastases, lesions did not enhance with MnDPDP. CONCLUSION: As a new contrast agent used in magnetic resonance imaging of the liver, MnDPDP is of some value in detecting hepatic lesions and in differential diagnosis.