Paediatric thrombo-embolism: the influence of non-genetic factors and the role of activated protein C resistance and protein C deficiency |
| |
Authors: | M. M. Uttenreuther-Fischer B. Vetter C. Hellmann U. Otting S. Ziemer G. Hausdorf G. Gaedicke A. E. Kulozik |
| |
Affiliation: | (1) Charité-Virchow Medical Center, Department of General Paediatrics, Augustenburger Platz 1, D-13353 Berlin, Germany Tel.: +49 30 45066351/2 Fax: +49 30 45066919, DE;(2) Charité-Virchow Medical Center, Institute for Pathological and Clinical Biochemistry, Schumannstrasse 20–21, D-10098 Berlin, Germany, DE;(3) Charité-Virchow Medical Center, Department of Paediatric Cardiology, Schumannstrasse 20–21, D-10098 Berlin, Germany, DE |
| |
Abstract: | In many children, the pathogenesis of thrombo-embolism remains unexplained. This study examines the role of non-genetic risk factors in 37 children with venous or arterial thrombosis. Included were 17 patients with portal vein thrombosis following umbilical vein catheterisation, 6 with portal vein thrombosis and an uneventful neonatal period, 4 with deep vein␣thrombosis, 4 with renal vein thrombosis after kidney transplantation, 1 haemodialysis patient with thromboses of arteriovenous shunts, and 5 with arterial thromboses at various sites. In 25 of these 37 patients (68%) exogenic risk factors and particularly vascular manipulations (24/37) were related to the thrombotic event. Resistance to activated protein C was identified in 5 patients and protein C deficiency in 2 (7/37; 19%). This prevalence was significantly higher than that of the control group (14/243; 5.8%; χ2, P < 0.008). Conclusion Our data show that non-genetic and particular iatrogenic risk factors can often be identified in children with thrombosis, but activated protein C resistance and protein C deficiency are significant genetic risk factors in this age group. Received: 23 April 1996 / Accepted: 1 August 1996 |
| |
Keywords: | Thrombosis Activated protein C resistance Protein C deficiency |
本文献已被 SpringerLink 等数据库收录! |
|