2型糖尿病合并胆石症与胰岛素抵抗相互关系的探讨

目的:探讨2型糖尿病合并胆石症与胰岛素抵抗之间关系.方法:测定35例2型糖尿病合并胆石症患者的空腹血糖、空腹胰岛素、三酰甘油,总胆固醇,高密度脂蛋白,低密度脂蛋白(LDL),并计算胰岛素敏感指数,观察其变化及相互关系,并与42例不伴胆石症的2型糖尿病患者相比较.结果:2型糖尿病并胆石症组与不伴胆石症组相比较,前者空腹胰岛素、三酰甘油、总胆固醇,低密度脂蛋白明显升高,胰岛素敏感指数明显下降.结论:胰岛素抵抗可能是2型糖尿病患者胆石形成的危险因素.

Relationship between insulin resistance and cholelithiasis in type 2 diabetes

Objective To investigate the relationship between insulin resistance and cholelithiasis in type 2 diabetes mellitus.Methods Fasting serum glucose,insulin,lipid levels were measured in 35 patients with cholelithiasis and in 42 patients without cholelithiasis.Insulin sensitivity indices(ISI) were calculated and their interrelation was analyzed.Results Diabetic patients with cholelithiasis had lower ISI(P<0.01),higher total cholesterol, triglyceride,and low density lipoprotein-cholesterol levels compared with the diabetic without cholelithiasis(P<0.01,P<0.05).There was no significant difference in high density lipoprotein-cholesterol between two groups(P>0.05).Conclusion Insulin resistance may be a risk for the development of cholelithiasis in type 2 diabetes mellitus.