绝经后肥胖女性骨密度与血管内皮功能的关系研究

目的 探讨绝经后肥胖女性中骨密度(BMD)与血管内皮功能的相关性.方法 选择自然绝经1～5年的单纯肥胖者(体重指数≥25kg/m2),年龄40～55岁,按照双能X线检测结果选择正常骨量组39例,骨量减少组37例和骨质疏松组19例.所有受试者测定体脂、BMD、骨矿含量(BMC)和血管内皮功能,包括血流介导的内皮依赖性血管舒张(EDD)和硝酸甘油介导的非内皮依赖性血管舒张.结果 骨质疏松组平均年龄和平均绝经时间显著高于正常骨量组和骨量减少组(P<0.05或P<0.01).骨质疏松组及骨量减少组BMD和BMC均显著低于正常骨量组(P<0.05或P<0.01).骨质疏松组EDD显著低于正常体重组和骨量减少组(分别为5.45±2.99、7.76±3.70和7.32±3.41,均P<0.05).相关分析显示各部位的BMD、BMC均与EDD相关(P<0.05和P<0.01).结论 肥胖女性绝经后骨质疏松与血管内皮功能异常有关,对绝经后肥胖女性低骨量人群干预治疗可能有助于防治动脉硬化及心血管疾病.

Relationship between bone mineral density and endothelial function in postmenopausal obese women

Objective To investigate the relationships between bone mineral density (BMD) and endothelial function in postmenopausal obese women.Methods 95 postmenopausal obese women were divided into normal BMD group (n=39), low BMD group (n=37) and osteoporosis group (n=19). The body adiposity, BMD, bone mineral content (BMC) and endothelial function included flow-mediated endothelium-dependent dilation (EDD) and nitroglycerin-mediated dilation were measured. Results The average of age and postmenopausal years in osteoporosis group was higher than normal BMD group and low BMD group (P<0.05 and P<0.01). BMD and BMC were lower in osteoporosis group and low BMD group than normal BMD group (P<0.05 and P<0.01). EDD in osteoporosis group was significantly decreased than normal BMD group and low BMD group(5.45±2.99, 7.76±3.70 and 7.32±3.41,respectively, all P<0.05). The correlate analysis showed that BMD and BMC were correlated with EDD (P<0.05 and P<0.01). Conclusion Osteoporosis is correlated with endothelial function in postmenopausal obese women. The early intervention for low BMD subjects may improve endothelial function and prevent cardiovascular disease.