Resistive Index in Rabbits with Experimentally Induced Hydronephrosis: Effect of Furosemide

RATIONALE AND OBJECTIVES: The purpose of this study in rabbits was to evaluate the effect of furosemide on resistive index (RI) in the diagnosis of partial hydronephrosis. MATERIALS AND METHODS: In 14 rabbits the left ureter was ligated by being tied to an angiographic guide wire. Doppler sonography was performed before and 1 and 6 hours, 1 and 3 days, and 1, 2, and 4 weeks after ureteral ligation. At each interval it was performed both before and after intravenous injection of saline and furosemide. RIs were compared (a) between obstructed and contralateral kidneys and (b) before and after furosemide administration, and the statistical significance of any differences was determined. RESULTS: Obstructed kidneys had significantly higher RIs than the contralateral kidneys before furosemide administration at five of seven postligation measurements and after furosemide administration at all seven. The differences between obstructed and contralateral kidneys were significantly higher after furosemide administration (P < .05). The increase in RI after furosemide administration was significantly greater in obstructed than in contralateral kidneys (P < .05). CONCLUSION: The results in a rabbit model indicate that Doppler sonography with furosemide administration is a valuable method for evaluating hydronephrosis. The administration of furosemide accentuates the difference in RI between obstructed and nonobstructed kidneys.