| MDS病人血清血管内皮生长因子水平检测 |
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| 引用本文： | 赵梅青,赵洪国,杜以萍. MDS病人血清血管内皮生长因子水平检测[J]. 青岛大学医学院学报, 2008, 44(1): 72-74 |
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| 作者姓名： | 赵梅青 赵洪国 杜以萍 |
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| 作者单位： | 青岛大学医学院附属医院血液内科,山东,青岛,266003;青岛市第八人民医院肿瘤血液科 |
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| 摘 要： | 目的 探讨血管内皮生长因子(VEGF)在骨髓增生异常综合征(MDS)病人血清中的表达,及其对于MDS发生发展及预后的意义.方法 用双抗体夹心酶联免疫吸附方法(ELISA)检测43例MDS 病人血清VEGF水平,其中RA组16例,RAS组6例,RAEB组14例,RAEBT组7例,分析其与MDS分型及临床因素的关系,以正常人和急性髓细胞白血病(AML)病人为对照组.结果 RA组、RAS组病人VEGF水平与正常对照相比无明显差异(P＞0.05),RAEB组、RAEBT组VEGF水平均明显高于RA、RAS及正常对照组(F=34.33,q=3.34～12.01,P＜0.05).血清VEGF水平与病人的外周血常规、骨髓原始细胞比例有关(F=2.46、32.58,q=2.80～11.54,P＜0.05).结论 VEGF水平与MDS的发展转归有关.
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| 关 键 词： | 骨髓增生异常综合征 血管内皮生长因子 血管新生 |
| 文章编号： | 1672-4488(2008)01-0072-03 |
| 修稿时间： | 2007-06-26 |
DETECTION OF SERUM VEGF IN PATIENTS WITH MYELODYSPLASTIC SYNDROME |
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| ZHAO MEI-QING,ZHAO HONG-GUO,DU YI-PING. DETECTION OF SERUM VEGF IN PATIENTS WITH MYELODYSPLASTIC SYNDROME[J]. Acta Academiae Medicinae Qingdao Universitatis, 2008, 44(1): 72-74 |
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| Authors: | ZHAO MEI-QING ZHAO HONG-GUO DU YI-PING |
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| Affiliation: | ZHAO MEI-QING,ZHAO HONG-GUO,DU YI-PING (Department of Hematology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China) |
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| Abstract: | Objective To evaluate the serum level of VEGF in myelodysplastic syndrome(MDS) patients,and its clinical significance in the development and prognosis of the disease. Methods The serum VEGF in 43 MDS patients was determined by enzyme linked immunosorbent assay(ELISA),of whom,the cases of type RA,RAS,RAEB and RAEBT were 16,6,14 and 7,respectively.Their relationship with the typing,clinical factors and MDS was analyzed.Thirty healthy volunteers and patients with acute myeloid leukemia served as controls. Resu... |
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| Keywords: | Myelodysplastic syndrome Vascular endothelial growth factor Angiogenesis |
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