心型游离脂肪酸结合蛋白定性检查在急性非ST抬高心肌梗死超早期鉴别诊断中的应用

目的:探索心型游离脂肪酸结合蛋白在急性非ST抬高心肌梗死超早期(小于3 h)的应用价值。方法:选取2009年-2011年我院就诊的127名NSTEMI患者,以急诊PCI术中造影结果、冠状动脉CTA结果以及发病后3个月随访等信息作为最终诊断,在发病超早期内定性测定H-FABP及定量测定cTnI,并进行统计。结果:在本研究入组的患者中,H-FABP与cTnI相比具有较好的敏感性和特异性;联合H-FABP与cTnI两项结果进行诊断,其敏感度、特异性、阳性预测值及阴性预测值均较高。结论:H-FABP有望作为急性心肌坏死监测的一项快速、准确、敏感、特异性的指标。

Early diagnosis with heart fatty acid binding protein(H-FABP) in NSTEMI

Objective:To explore the application value of H-FABP in NSTEMI early diagnosis.Methods: 127 NSTEMI patients in our hospital from 2009 to 2011 were selected with PCI,CTA results and followup data after incidence for 3 months as the diagnostic criteria.Then H-FABP and cTnI were determined and conducted statistic analysis in early period of NSTEMI.Results: Compared with cTnI,H-FABP showed higher sensitivity and specificity,and combining H-FABP with cTnI,the sensitivity,specificity,positive and negtive predictive values indicated the combination had the highest value in diagnosis of NSTEMI.Conclusion: H-FABP is one of the most useful methods in the early diagnosis of NSTEMI.