| ACE、PAI-1基因多态性与T2DM患者合并冠心病的关系 |
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| 引用本文： | 刘玉华,梁雪玲,莫笑莲,黄秋霞.ACE、PAI-1基因多态性与T2DM患者合并冠心病的关系[J].中国误诊学杂志,2009,9(28):6807-6808. |
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| 作者姓名： | 刘玉华 梁雪玲 莫笑莲 黄秋霞 |
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| 作者单位： | 1. 广东省东莞市人民医院,综合科,523018
2. 广东省东莞市人民医院,内分泌科,523018 |
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| 摘 要： | 目的：探讨血管紧张素转换酶（angiotensin 1-converting enzyme，ACE）基因、纤溶酶原激活物抑制物-1（plasminogen activator inhibitor-1，PAI-1）基因多态性与2型糖尿病（type 2 diabetes，T2DM）患者冠状动脉粥样硬化性心脏病（coronary heart disease，CHD）的关系。方法：对100例单纯T2DM患者、60例T2DM合并冠心病患者进行ACE基因、PAI-1基因多态性检测，比较两组患者基因型及等位基因分布频率的差异；并进行Logistic多元回归分析影响T2DM患者冠心病的危险因素。结果：冠心病组患者PAI-1基因型频率、4G等位基因频率携带者比例较单纯T2DM患者显著增高（P〈0．05）Logistic多元回归分析发现冠心病和PAI-1基因型密切相关。结论：PAI-1基因多态性可能是T2DM患者合并冠心病的危险因素。
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| 关 键 词： | 肽基二肽酶A／遗传学 纤溶酶原激活物抑制物1／遗传学 多态现象 遗传 糖尿病 2型／并发症 冠状动脉疾病／并发症 人类 |
Relationship between Polymorphisms of PAI-1 Gene,ACE Gene and T2DM Combined with Coronary Heart Disease |
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| Institution: | LIU Yu-hua ,LIANG Xue-ling ,MO Xiao-lian ,et al. (Gerenal Departnent,People＇s Hospital of Dongguan,Dongguan 523018,China) |
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| Abstract: | Objective：To investigate the relationship between ACE,PAI-1 gene polymorphisms and T2DM with coronary heart disease. Methods ：The polymorphisms of ACE （I/D） gene and PAI-1 （4G/5G） gene in 160 cases were analyzed. Logistic regression analysis was used to disclose the correlation between the CHD and ACE （I/D） and PAI-1 （4G/5G） polymorphisms. Results ：The frequencies of PAI-1 gene type and 4G allele in CHD patients were increased （P〈0.05 ,P〈0. 001 ,respectively）compared with patients with T2DM. In logistic regression analysis ,CHD were related to HbAlc and PAI-1 genotype. Conclusions ：The PAI-1 4G/4G genotype is independent risk factors for CHD withT2DM. |
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| Keywords: | Peptidyl-Dipeptidase A/genetics Plasminogen Activator Inhibitor 1/genetics Diabetes Mellitus Type 2/ complications Coronary Disease/complications Humans |
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