赤土茯苓苷对大鼠心肌缺血的保护作用

目的：研究赤土茯苓苷（Ｓｍｉｇｌａｂｒｉｎ，Ｓｍｉ）对大鼠心肌缺血的保护作用。方法：采用结扎冠脉造成大鼠心有缺血的模型，测量大鼠心肌梗塞面积、心电图（ＥＣＧ）Ｓ－Ｔ段抬高幅度，测定心肌组织中ＳＯＤ，ＣＰＫ，ＭＤＡ和ＦＦＡ的活性和含量。结果：结扎冠脉后，心肌中ＳＯＤ，ＣＰＫ活性降低，ＭＤＡ，ＦＦＡ含量升高，心电图表现为Ｓ－Ｔ段升高，预先给予大白鼠大剂量Ｓｍｉ１００ｍｇ／ｋｇ和小剂量Ｓｍｉ５０ｍｇ／ｋ

Protective Effects of Smiglabrin in Acute Myocardial Infarcted rats by ligation of Left Coronary Artery

Objective: The aim of the present study was to investigate protective effects of Smiglabrin (Smi) in acute myocardial infarction rats. Methods: Myocardial ischemia model was made ligating the left coronary artery of rats. The area of infarction and S T segment in ECG were observed, SOD and CPK activities, MDA and FFA contents were measured. Results: After the left coronary artery of rat was ligated, the activities of SOD and CPK were decreased, the concentrations of MDA and FFA were increased, S T segment in ECG was elevated, But if rats were administrated before experiment by Smi 50 mg/kg. d=7, 100 mg/kg. d=7,ip the amplitude of S T segment elevation was decreased, the area of infarction was reduced, the activities of SOD and CPK were increased, the concentrations of MDA and FFA were decreased. Conclusions: Smi may enhance the SOD and CPK activities, inhibite the MDA and FFA formation, to protect the ischemia myocardium by ligating the left coronary artery.