Cystatin C in the human pancreas and gut: An immunohistochemical study of normal and neoplastic tissues |
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Authors: | Helén Lignelid Björn Jacobsson |
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Institution: | (1) Department of Clinical Chemistry and Pathology, Danderyd Hospital, S-18288 Danderyd, Sweden |
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Abstract: | Summary The occurrence of immunoreactive cystatin C (CC) in normal and neoplastic cells of the human pancreas and gut was investigated using an indirect streptavidin-biotin method on formaldehyde-fixed and paraffin-embedded tissues. Virtually all pancreatic islet cells and many neuroendocrine cells throughout the gastrointestinal tract showed strong CC immunoreactivity and a granular cytoplasmic staining pattern. All 14 endocrine pancreatic tumours (insulinomas, glucagonomas, gastrinomas and non-producing tumours), as well as 16 of 17 gut carcinoid tumours, were also strongly CC immunoreactive. In addition, non-endocrine epithelial cells of pancreatic ducts and the gastrointestinal mucosa and 20 of the 24 adenocarcinomas from these sites showed weak CC immunoreactivity. Thus, CC cannot be used as a reliable immunohistochemical marker for endocrine gastro-entero-pancreatic tumours despite the fact that the protein is strongly expressed in a majority of such tumours. |
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Keywords: | Cystatin Immunohistochemistry Pancreas Gut Endocrine tumours Adenocarcinomas |
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