Influence of verapamil and diltiazem on the muscle-relaxing effect of atracurium in vivo] |
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| Authors: | E Gómez Iglesias E García Pascual C Aguirre Gómez J M Rodríguez-Sasiaín R Calvo Duo |
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| Affiliation: | Departamento de Farmacología, Hospital de Galdakao. |
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| Abstract: | The interaction between atracurium and the two calcium antagonists verapamil and diltiazem were studied in rabbits. It was observed that intravenous verapamil (0.2 mg/kg) reduced by 25% and 30% respectively, the dose of atracurium required to produce a 50% or 95% of neuromuscular blockade. In contrast, intravenous diltiazem (1 mg/kg) failed to produce significant changes. |
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