雄激素受体及雄激素在老年男性高血压患者中的变化及意义

目的探讨男性高血压患者性激素水平的变化,并进一步研究性激素与高血压患者雄激素受体、肥胖的相关性。方法收集高血压患者112例,正常健康者120例,记录临床资料,包括身高、体重、年龄。采用酶联免疫吸附法及化学发光法检测血浆总睾酮(TSTO),游离睾酮(FT),脱氢表雄酮硫酸酯(DHEAS),性激素结合球蛋白(SHBG),雌二醇(E2),黄体生成素LH),卵泡刺激素(FSH)水平。用流式细胞术测定外周血白细胞雄激素受体(AR),以上各项指标在两组之间进行比较。结果高血压患者总睾酮(TSTO)浓度明显低于正常对照组,差异有显著性(P<0．05)。高血压组体重指数、腰围／臀围、E2／T与正常对照组相比均存在显著性差异(P<0．05)。高血压患者血浆总睾酮与雄激素受体含量、体重指数呈显著相关,分别与雄激素受体含量正相关(r=0．08,P<0．01);与体重指数负相关(r=-0．58,P<0．01)。结论血浆雄激素水平可作为评估高血压发病危险因素的一项新指标。

Change of Sex Hormone and Androgen Receptor in Men Hypertension Patients

Objective To estimate the plasma sex hormones level in men hypertension patients, and to investigation the correlation of plasma sex hormones with androgen receptor as well as fatness. Methods 232 subjects were involved in this clouding 112 hypertension patients and 120 health controls. Enzyme linked immunosorbent assay (ELISA) technique was used to detection the plasma sex hormones concentration. We measured androgen receptor by means of flow cytometry. The results were compared between men hypertension patients and elderly healthy men. Results The levels of plasma TT and . body mass index ( BMI) were increased significantly in hypertension group compared with control group (P <0. 05) . the level of TT was positively correlated with androgen receptor and was negatively correlated with BMI ( P <0. 01) . Conclusion TT could be as j 1 as a new indicator to evaluate the risk to develop hypertension disease.