Anticonvulsant action of amino acid antagonists against kindled hippocampal seizures |
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Authors: | D.W. Peterson J.F. Collins H.F. Bradford |
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Affiliation: | Department of Physiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu 807 Japan |
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Abstract: | Single unit recordings were made from neurons of the subfornical organ (SFO) in hemispherectomized cats following electrical stimulation in the paraventricular nucleus (PVN) of the hypothalamus. Of 132 neurons tested, 48 (36%) were inhibited, 3 (2.3%) excited and two (1.5%) antidromically activated. In separate experiments the wall of the third ventricle near the PVN was locally perfused with glutamate solution using a concentric push-pull cannula. Of 35 SFO neurons tested, 6 were inhibited, 5 were facilitated and 24 unaffected. The results indicate that one-third of SFO neurons receive synaptic inputs from cells in or near the PVN. |
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Keywords: | kindling hippocampus amino acid antagonist glutamate anticonvulsant |
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