Norplant~R Ⅰ和CLa长期埋植者的细胞遗传学效应对比研究 |
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作者姓名: | Yin Jiaoyang 1,Sun Xiaoling 2,Liu Quanzhang 3 1 Biology Section,Shenyang Medical College,Shenyang 110031,2 Section of Genetics and Eugenics,Liaoning Research Institute of Family Planning,Shenyang 110031,3 Biology Section,Harbin Medical Colle |
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作者单位: | Yin Jiaoyang 1,Sun Xiaoling 2,Liu Quanzhang 3 1 Biology Section,Shenyang Medical College,Shenyang 110031,2 Section of Genetics and Eugenics,Liaoning Research Institute of Family Planning,Shenyang 110031,3 Biology Section,Harbin Medical Colle |
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摘 要: | 对长期皮下埋植NorplantRⅠ型和CLa型避孕药剂的妇女和正常对照组的妇女的染色体畸变、姊妹染色单体互换及细胞微核等细胞遗传学指标进行了研究。结果提示:NorplantRⅠ型可增加其应用者体内细胞诱变性环境的存在,使其染色体畸变率和姊妹染色单体互换率显著性增加,且有统计学意义,故应引起对长期皮下埋植NorplantRⅠ型长效避孕皮埋药剂是否存在致突变作用问题的重视和进一步研究。CLa型长效避孕皮下埋植药剂未发现有明显的致突变作用,从细胞遗传学角度上看是安全的。
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关 键 词: | Norplant~R Ⅰ型;CLa型;长期皮下埋植避孕;细胞遗传学 |
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