无抽搐电休克对抑郁症患者疗效及血清脑源性神经营养因子的影响

目的分析抑郁症患者应用无抽搐电休克治疗对患者疗效及血清脑源性神经营养因子的影响。方法将80例抑郁症患者,按照入院先后顺序随机分为研究组和对照组各40例。所有患者采用艾司西酞普兰治疗,研究组外加无抽搐电休克治疗。比较2组患者汉密尔顿抑郁量表（HAMD）和临床变化总体评价量表（CGI）得分等。结果治疗前,2组患者脑源性神经营养因子（brain-derived neurotrophic factor,BDNF）水平差异无统计学意义（P〉0.05）;治疗后,2组患者均显著升高（P〈0.05）,且研究组显著优于对照组（P〈0.05）。研究组治疗有效率为92.50%（37/40）,对照组为82.50%（33/40）,差异有统计学意义（P〈0.05）。2组患者治疗前后HAMD、HAMA以及CGI、认知功能均得到显著改善（均P〈0.05）。结论无抽搐电休克治疗抑郁症患者,可有效改善患者抑郁、焦虑以及认知功能,提高患者BDNF水平,对患者性功能不会产生影响。

The effects of non-convulsive electric shock therapy on depression and serum brain derived neurotrophic factors

Objective To examine the effects of non-convulsive electric shock therapy on depression and serum brain-derived neurotrophic factors. Method 80 patients of depression were randomly divided into an experimental group （ n = 40） and a control group （n = 40）. The control group was treated with Ai Seiplan only while the experimental group was treated with non convulsive electric shock therapy in addition to Ai Seiplan. The scores calculated with Hamilton Depression Scale （HAMD） and clinical changes in overall assessment scale （CGI） that the two groups achieved were then compared. Findings Before treatment, the brain derived neurotrophic factors （BDNFs） between the two groups bore no statistically significant difference （ P 〉 0.05 ）. After the treatment, the factors in both patients increased considerably（ P 〈 0.05 ） , with the experimental group＇s factors having a greater increase than that of the control group （ P 〈 0.05 ）. The effective rate of treatment of the experimental group was 92.50% （37/40） , while that of the control group was 82.50% （33/40）. The difference was statistically significant （ P 〈 0.05）. Before and after treatment, the HAMD, HAMA and CGI, cognitive function of both groups improved significantly （ P 〈 0.05 ）. Conclusion The study indicated that non-convulsive electric shock therapy could effectively ease depression and anxiety, improve cognitive function and the level of BDNF, but bear no side effects on patients＇ sexual function.