| 妊娠肝内胆汁淤积症胆酸与EPO变化及其临床意义 |
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| 引用本文： | 闵羡蕙,张敏,陈秋鸳,黄美霞.妊娠肝内胆汁淤积症胆酸与EPO变化及其临床意义[J].山西医科大学学报,2008,39(4):366-369. |
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| 作者姓名： | 闵羡蕙 张敏 陈秋鸳 黄美霞 |
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| 作者单位： | 1. 南京军区解放军福州总医院九五临床部妇产科,莆田,351100
2. 福建莆田学院医学院生理教研室 |
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| 摘 要： | 目的 观察妊娠期肝内胆汁淤积症(ICP)孕妇静脉血、羊水、脐血中胆酸、促红细胞生成素(EPO)变化及其相关性研究,探讨其临床意义. 方法 对52例ICP患者采用酶联免疫吸附试验(ELISA)和放免法(RIA)测定孕妇血、羊水、脐静脉血中胆酸及EPO水平;另选取46例正常足月妊娠孕妇作对照组;胎儿娩出时抽取脐动脉血进行血气分析以判定是否缺氧.结果 ICP组孕妇血、脐静脉血及羊水中胆酸水平显著高于对照组;ICP组孕妇血EIK)水平同对照组相比差异无统计学意义(P>0.05),ICP组妇女的胎儿脐静脉血及羊水中EPO含量均明显低于对照组胎儿的水平(均P<0.05),ICP组中缺氧胎儿的脐静脉血EPO水平明显低于未发生缺氧胎儿的水平,ICP组孕妇血、脐静脉血及羊水中胆酸与脐静脉血、羊水的EPO分别成负相关. 结论 ICP孕妇血清高胆酸水平对胎儿体内合成EPO有一定影响;胎儿EPO水平低下是其宫内缺氧的原因之一;检测羊水EPO可以作为产前监测ICP胎儿官内缺氧的一项参考指标.
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| 关 键 词： | 胆汁淤积症 缺氧 促红细胞生成素 胆酸 新生儿 妊娠肝内胆汁淤积症 胆酸 变化 临床 统计学意义 significance pregnancy cholestasis erythropoietin 参考指标 产前监测 检测 宫内缺氧 影响 合成 清高 负相关 发生 胎儿脐静脉血 含量 |
| 文章编号： | 1007-6611(2008)04-0366-04 |
| 修稿时间： | 2007年11月1日 |
Changes of erythropoietin and cholyglycine in intrahepatic cholestasis of pregnancy and their significance |
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| MIN Xian-hui,ZHANG Min,CHEN Qiu-yuan,HUANG Mei-xia.Changes of erythropoietin and cholyglycine in intrahepatic cholestasis of pregnancy and their significance[J].Journal of Shanxi Medical University,2008,39(4):366-369. |
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| Authors: | MIN Xian-hui ZHANG Min CHEN Qiu-yuan HUANG Mei-xia |
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| Institution: | 1Dept of Obstetrics and Gynecology;Nine Five Clinical Department of Fuzhou General Hospital;Nanjing Military;Chinese People's Liberation Army;Putian 351100;China;2Dept of Physiology;Medical College of Putian University |
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| Abstract: | Objective To investigate the changes of erythropoietin and cholyglycine in amniotic fluid and umbilical blood in intrahepatic cholestasis of pregnancy(ICP)and their relations,and to explore their clinical value.Methods ELISA and radioimmunoassay(RIA)were used to examine the levels of erythropoietin and cholyglycine in serum,amniotic fluid and umbilical blood in 52 pregnant women with ICP(ICP group)and 46 normal pregnant women(control group).Umbilical cord arterial blood gas analysis of newborn fetus was use... |
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| Keywords: | intrahepatic cholestasis hypoxia erythropoietin cholyglycine newborn |
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