| 鸡骨常山根中三个新吲(口朶)生物碱的分离和鉴定 |
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| 引用本文： | 陈未名,阎雅平,王永寄,梁晓天.鸡骨常山根中三个新吲(口朶)生物碱的分离和鉴定[J].药学学报,1985,20(12):906-912. |
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| 作者姓名： | 陈未名 阎雅平 王永寄 梁晓天 |
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| 作者单位： | 中国医学科学院药物研究所,北京;**吉林省中医中药研究所,进修生 |
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| 摘 要： | 从云南产鸡骨常山(Alstonia yunnanensis Diels)根中又分离得9个吲哚生物碱和一个非碱成分。根据理化性质和UV、IR、NMR及MS等光谱数据,推断三个新碱是去乙酰匹克林拉三甲氧基苯甲酸酯(deacetylpicraline 3,4,5-trimethoxybenzoate Ⅵ),17-乙酰蛇根精(17-acetylsarpagine Ⅺ)和16-差向蛇根精(16-episarpagine Ⅻ)。六个为已知碱。
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| 关 键 词： | 夹竹桃科 鸡骨常山 吲哚生物碱 去乙酰匹克拉林三甲氧基苯甲酸酯 17-乙酰蛇根精 16-差向蛇根精 11-甲氧基-19-羟基它勃水甘 |
| 收稿时间： | 1984-11-05 |
ISOLATION AND IDENTIFICATION OF THREE NEW ALKALOIDS. FROM ROOTS OF ALSTONIA YUNNANENSIS DIELS INDIANA, USA |
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| CHEN Wei-Ming,YAN Ya-Ping,WANG Yong-Ji and LIANG Xiao-Tian.ISOLATION AND IDENTIFICATION OF THREE NEW ALKALOIDS. FROM ROOTS OF ALSTONIA YUNNANENSIS DIELS INDIANA, USA[J].Acta Pharmaceutica Sinica,1985,20(12):906-912. |
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| Authors: | CHEN Wei-Ming YAN Ya-Ping WANG Yong-Ji and LIANG Xiao-Tian |
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| Abstract: | In a previous paper, the isolation and identification of six known indole alkaloids form Alstonia Yunnanensis Diels was reported. This paper reports the isolation of nine other indole alkaloids and a nonalkaloidal component. They are lochnerinine (Ⅰ), 11-methoxy-19-hydroxytabersonine (Ⅱ), pseudoakuammigine (Ⅳ), picrinine (Ⅴ), deacetylpicraline 3, 4, 5- trimethoxybenzoate (Ⅵ), corynanthine (Ⅸ), yohimbine (Ⅹ), 17-acetylsarpagine (Ⅺ), 16-episarpagine (Ⅻ) and methyl 3, 4, 5-trimethoxycinnamate. Their structures were elucidated by spectroeopic analysis (UV, IR, NMR, MS), physical constants and preparation of derivatives. It has been shown that Ⅵ, Ⅺ and Ⅻ are new indole alkaloids. |
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| Keywords: | Alstonia yunnanensis Indole alkaloids deacetylpicraline 3 4 5-trimetlioxybenzoate 17-Acety lsarpagine 16-Episarpagine Apocynaceae |
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