盐酸法舒地尔防治脑血管造影致血管痉挛的临床观察

目的观察盐酸法舒地尔防治脑血管造影术所致脑血管痉挛的临床效果。方法将120例行脑血管造影的患者随机分为观察组(60例)和对照组(60例),对照组术前30 min肌内注射苯巴比妥钠0.2 g,观察组在此基础上应用盐酸法舒地尔60mg静脉缓慢滴入,持续至造影后30 min。结果观察组术后2例发生脑血管痉挛,发生率为3.3%;对照组出现脑血管痉挛10例,发生率为16.7%,差异有统计学意义(χ2=4.537,P0.05)。结论脑血管造影术中静脉滴入盐酸法舒地尔可防治脑血管痉挛的发生,且安全可靠。

Clinical observation of hydroxyl fasudil in prevention and treatment of DSA-induced cerebral spasm

Objective To observe the effect of hydroxyl fasudil in prevention and treatment of DSA-induced cerebral vascular spasm.Methods A total 120 cases of ischemic cerebrovascular patients with digital subtraction angiography(DSA) examination were randomly divided into 2 groups(n=60,in each group): study group and control group.Besides receiving traditional treatment,60mg of hydroxyl fasudil was used as intravenous drip 30 minutes before DSA.The treatment of the control group was similar to those of study group except for hydroxyl fasudil.Results 2 cases of vascular spasm were observed in study group(3.3%),10 cases of vascular spasm were observed in control group(16.7%).The incidence rate of DSA-induced cerebral vascular spasm in study group was lower than that of control group(χ2=4.537,P<0.05).Conclusion Hydroxyl fasudil can degrade the incidence rate in prevention and treatment of DSA-induced cerebral vascular spasm.Hydroxyl fasudil is safe in clinical application.