氨溴索 PS及联合nCPAP预防早产儿呼吸窘迫综合征的疗效比较

目的比较氨溴索、肺表面活性物质(PS)及联合nCPAP预防早产儿呼吸窘迫综合征(NRDS)的疗效。方法回顾性分析109例早产儿使用氨溴索、肺表面活性物质及联合nCPAP预防NRDS的血气指标、吸氧时间、并发症、对机械通气需求、住院时间及病死率。结果 3种治疗方法均可以迅速改善患儿的血气指标,与PS组和氨溴索+nCPAP组相比,PS+nCPAP组PaO2升高(F=38.050,P=0.000)、PaCO2下降(F=23.618,P=0.000)和血pH值(F=44.072,P=0.000)恢复更为理想;PS+nCPAP组吸氧时间最短(F=7.422,P=0.001),且住院时间最短(F=3.409,P=0.037)。结论 PS联合nCPAP预防早产儿NRDS效果最佳,但氨溴索联合nCPAP更为经济,适用于某些无条件使用PS的患儿。

Effects of ambroxol,pulmonary surfactant and nCPAP on NRDS prevention in premature infants

Objective To evaluate the effects of ambroxol、pulmonary surfactant(PS) and nCPAP on neonatal respiratory distress syndrome(NRDS) in premature infants.Methods We performed a retrospective analysis of 109 premature infants which was born at 28 to 37 weeks of gestation admitted from 2008 to 2010 in our hospital.All children received ambroxolor PS or PS+nCPAP treatment respectively.Blood gases,oxygen time,complications,ratio of mechanical ventilation,length of stay and mortality were determined.Results Blood gases were all improved after the three treatments.The PS combined with nCPAP was better than others methods.The increased Pa02 level(F=38.050,P=0.000),decreased PaCO2 level(F=23.618,P=0.000)and pH value(F=23.618,P=0.000)were all improved.Meanwhile,the length of stay(F=3.409,P=0.037)and oxygen times(F=7.422,P=0.001)were obviously shortened than other methods.Conclusion The PS+nCPAP is the best efficient method in premature infants with NRDS treatment.But ambroxol+nCPAP is worth recommending to developing areas or basement hospitals.