白血病C-MyC癌基因的表达(附10例白血病分析)

本文检测10例白血病C-myC癌基因在蛋白质水平上的表达,发现4例不缓解白血病的C-myC阳性细胞百分比以及C-myC总的表达量明显高于缓解期病人的表达,2例病人临床及骨髓象已达缓解,但C-myC蛋白阳性细胞百分数及C-myC蛋白总表达量仍维持高水平表达,分别于28天及37天复发。这提示,C-myC蛋白的表达水平是预示白血病复发的更敏感的指标。另外,10例白血病病人的C-myC阳性细胞百分数均较骨髓内幼稚细胞百分数为高,提示一部分形态上看来是正常的细胞,仍有C-myC的表达,这部分细胞很可能是白血病细胞。

THE EXPRESSION OF C-MYC ONCOGENE IN 10 PATIENTS WITH LEUKEMIA (ABSTRACT)

The expression of C-myC oncogene was studied at the protein level incells obtained from 10 patients with leukemia. Expression of C-myConcogene in 4 patients without remission was much higher than thatin other 3 patients with remission. 2 cases was examined who had beenremission in clinic and in amount of bone marrow blast cells but whoseexpression of C-myC and the amount of C-myC positive cell was stillkeeped at high level. They had relapse after lmonth. this data suggestedthat expression of C-myC oncogene in protein level could predictwhether leukemia relapse in future as more susceptible indicater thanthat in the bone marrow morphology. In other hand amount of C-myCpositive cells in bone marrow of all 10 cases was more than that ofblast cells, suggesting that some leukemic cells which can not bedetectable in morphology of cells can be detected.