| 低分子肝素治疗抗磷脂综合征疗效及对骨代谢影响的探讨 |
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| 引用本文： | 李萍,朱付凡. 低分子肝素治疗抗磷脂综合征疗效及对骨代谢影响的探讨[J]. 实用妇产科杂志, 2008, 24(11) |
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| 作者姓名： | 李萍 朱付凡 |
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| 作者单位： | 1. 中南大学湘雅二医院,湖南,长沙,410011;长沙市妇幼保健院,湖南,长沙,410007
2. 中南大学湘雅二医院,湖南,长沙,410011 |
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| 摘 要： | 目的:比较低分子肝素与强的松和阿司匹林治疗抗磷脂综合征(APS)的疗效及对骨代谢的影响,探讨低分子肝素是否能替代强的松和阿司匹林治疗APS.方法:将抗心磷脂抗体(ACA)阳性患者80例(已孕40例,未孕40例)随机分为研究组及对照组,每组为40例.研究组予以低分子肝素(克塞),对照组予以强的松与阿司匹林治疗,观察治疗后两组ACA转阴率,对血液流变学、骨代谢及妊娠结局的影响.结果:①随治疗时间延长,研究组与对照组ACA转阴率均增加,差异无统计学意义(P＞0.05).②研究组治疗前后抗酒石酸酸性磷酸酶(TRAP)浓度,差异均无统计学意义(P＞0.05);对照组治疗前后,差异均有统计学意义(P＜0.05),研究组治疗后TRAP浓度均比对照组上升幅度小,差异均有统计学意叉(P＜0.05).③治疗后研究组与对照组妊娠成功率差异无统计学意义(P＞0.05).结论:低分子肝素治疗抗磷脂综合征,其ACA转阴率、妊娠结局与强的松和阿司匹林相当,降低血浆粘度优于强的松和阿司匹林,对骨代谢影响比强的松和阿司匹林小.
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| 关 键 词： | 抗磷脂综合征 低分子肝素 血浆粘度 抗酒石酸酸性磷酸酶 血钙 |
Study of Low Molecular Heparin on Women with Antiphospholipid Syndrome and its Influence of Bone Metabolism |
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| LI Ping,ZHU Fufan. Study of Low Molecular Heparin on Women with Antiphospholipid Syndrome and its Influence of Bone Metabolism[J]. Journal of Practical Obstetrics and Gynecology, 2008, 24(11) |
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| Authors: | LI Ping ZHU Fufan |
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| Affiliation: | LI Ping1,2,ZHU Fufan1 (1.Second Xiangya Hospital Affiliated to Central South University,Changsha Hunan 410011,China,2.Maternal , Child Hospital of Changsha,Changsha Hunan 410007,China) |
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| Abstract: | Objective:To compare the therapeutic effect of low molecular heparin with prednisone plus aspirin on antiphospholipid syndrome and their influence on bone metabolism,hemorheology and pregnancy outcome.Methods: A prospective observational study included 40 patients(20 pregnant,20 unpregnant) with anticardiolipin antibody in the study group who received low-molecular heparin.The control group had 40 patients,(20 pregnancy patients,20 unpregnancy patients) received prednisone and aspirin.Pregnancy outcomes,neg... |
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| Keywords: | Anticardiolipin antibody Antiphospholipid syndrome Low-molecular heparin :Tartrate-resistand acid phosphatase Blood calcium |
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