| 扑热息痛致急性肝功能衰竭狗肝脏血流动力学和血浆儿茶酚胺的变化 |
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| 引用本文： | 赵秋,张柳清,李道芬.扑热息痛致急性肝功能衰竭狗肝脏血流动力学和血浆儿茶酚胺的变化[J].实用肝脏病杂志,1998(1). |
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| 作者姓名： | 赵秋 张柳清 李道芬 |
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| 作者单位： | 广州军区武汉总医院消化内科，同济医科大学同济医院小儿科，广州军区武汉总医院消化内科 430070 武汉市，430070 武汉市 |
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| 摘 要： | 本实验通过建立扑热息痛致狗急性肝功能衰竭模型,观察了肝脏血流动力学改变和外周及内脏血管床血浆儿茶酚胺浓度的变化。结果为:急性肝功能衰竭时门静脉阻力明显增加,肝动脉血管阻力下降;门静脉血流量明显减少,总肝血流量亦明显降低,肝动脉血流量、门静脉压力及嵌塞静脉压力均无明显变化;门静脉、肝静脉、腹主动脉、下腔静脉血浆去甲肾上腺素浓度均明显增加。后者可能收缩门脉血管床,增加门静脉阻力、参与和/或加重肝循环障碍,本研究支持用酚妥拉明等α受体阻滞剂治疗急性肝功能衰竭时肝脏血流动力学障碍。
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| 关 键 词： | 扑热息痛 急性肝功能衰竭 血流动力学 儿茶酚胶 |
DISORDERS OF HEPATIC HEMODYNAMICS AND CHANGES OF PLASMA CATECHOLAMINES IN ACETAMINOPHEN - INDUCED FULMINANT HEPATIC FAILURE DOGS |
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| Zhao Qiu Zhang Liu-Qiu Li Duo Fen.DISORDERS OF HEPATIC HEMODYNAMICS AND CHANGES OF PLASMA CATECHOLAMINES IN ACETAMINOPHEN - INDUCED FULMINANT HEPATIC FAILURE DOGS[J].Journal of Clinical Hepatology,1998(1). |
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| Authors: | Zhao Qiu Zhang Liu-Qiu Li Duo Fen |
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| Institution: | Zhao Qiu Zhang Liu-Qiu Li Duo FenDepartment of Gastroenterology,Wuhan General Hospital of PLA,Wuhan 430070Department of Pediatrics,Tongji Hospital,Tongji Medical University |
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| Abstract: | The model of fulminant hepatic failure induced by acetaminophen was established in dogs to ob serve the changes of hepatic hemodynamics and plasma catecholamines levels in portal vein, hepatic vein,abdominal aorta and inferior vena cava.The results showed that the plasma norepinephrine levels in the four vessels didn't significantly change.The portal venous vessel resistance was elevated and portal venous blood flow was decreased.These finding indicated that the increase of plasma norepinephrine might play an important role in the changes of hepatic hemodynamics in this acute hepatic failure mod el. |
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| Keywords: | Catecholamine Norepinephrine Epinephrine Fulminant Hepatic Failure |
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