Relation between bone marrow angiogenesis and serum levels of angiogenin in patients with myelodysplastic syndromes |
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| Authors: | Alexandrakis Michael G Passam Freda H Pappa Constantina A Sfiridaki Katerina Tsirakis George Damilakis John Stathopoulos Efstathios N Kyriakou Despina S |
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| Institution: | Department of Haematology, University Hospital of Heraklion, Medical School of Crete, P.O. Box 1352, Heraklion, Crete, Greece. freda@med.uoc.gr |
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| Abstract: | Angiogenesis is implicated in the progression of myelodysplastic syndromes (MDS). Bone marrow microvascular density (MVD), serum angiogenin (ANG) and interleukin 6 (IL-6) were measured in 67 patients with untreated MDS. MVD, ANG and IL-6 were significantly higher in the patient group as a whole when compared to controls (P < 0.01). MVD and ANG were significantly higher in subtypes with a high-risk for leukemic transformation (RAEB, RAEB-t and CMML) than in low-risk subtypes (RA and RARS) (P < 0.01). In the MDS group, a positive correlation was found between ANG and IL-6 (P < 0.001) and also between MVD and IL-6 (P < 0.05). Using multivariate analysis, only IL-6 displayed independent prognostic value and was inversely related to MDS survival. |
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