中药引经药中引经化学成分的探讨

目的探讨中药引经药中存在的起引经作用的化学成分,从而更加明确"引经报使"理论的科学性,为今后探寻、提取和研制引经制剂指明方向并提供理论依据。方法通过文献调研,从已知的实验研究结果和临床应用效果中分析、推理和归纳演绎出引经成分的理论。结果经过大量的文献调研,发现引经中药中的某些化学成分如桔梗皂苷类、川芎嗪和芳香烃类等许多活性成分均有各自的主动选择性,能主动进入靶点部位,类似于引物、启动子、递质、介质、介导体、转导子、转运体等主动靶向性载体的功能。结论在中医引经理论的指导下,运用现代科学技术,完全可以从这些已知的化学成分中筛选出最具引导作用的活性成分,抑或能够发现起独特引导作用的"亲和素"或"靶向子"活性成分,为今后研制专门的"引经制剂"提供物质基础,更为验证中医药引经理论、发展中医药理论铺平道路。

Exploration on the Guiding Chemical Constituents in the Medicinal Guides of Traditional Chinese Medicinal Herbs

Objective To explore the chemical constituents that play a guiding role existing in the medicinal guides of the traditional Chinese medicinal herbs,so that to make it more scientific of the theory"guiding actions".Methods By investigating the literatures,the author made the analysis,derivation,induction and deduction on the theory of the guiding constituents from the known experimental results and clinical outcomes.Results Through a large number of the literature investigations,in the medicinal guides,some chemical constituents such as Platycodosides,3H-ligustrazine and aromatics,etc were found to have their own selectivity and the ability to actively enter the targetable sites,similar to the active target-tropism functions of primer,promoter,transmitter,mediator,transductor and transporter,etc.Conclusion Under the instruction of TCM guiding theory,adopting modern science and technology,researchers would entirely enable to screen the bioactive components possessing the best guiding actions from the known chemical components of the medicinal guides.Perhaps they could discover some bioactive components possessing the peculiar guiding actions,such as "affinitin" or "targeter".It is possible to provide the essential substances for preparing the special "guiding agents" and also do the theoretical evidence for examining the TCM guiding theory and paving the plain way for developing TCM theory.