Model of atrophic gastritis in rats by various method]

Model of atrophic gastritis was made in rats by synthetical method which comprised twice of active immunization and continual oral administration of bile and hot water for 70 days. There was a highly significant difference (P less than 0.01) between the normal group and testing group in the number of rats with changes in body-weight, PH value of gastric mucous membrane, gastric membrane blood flow (GMBF) and its potential difference (PD), and pathology (thinned mucous membrane, decreased gland, infiltration of inflammatory cells and intestinal metaplasia). By observations for additional 45 days, the above-mentioned values still showed significant or highly significant differences (P less than 0.05 or P less than 0.01) between the testing group and the normal group. The animal model of atrophic gastritis made by this method can be used for the valuation of drug efficacy.