子痫前期患者肝肾功能的改变及对胎儿的影响

目的 探讨子痫前期患者肝肾功能指标的改变及对妊娠结局的影响.方法 选择我院100例轻度子痫前期患者、110例重度子痫前期患者以及100例正常晚孕妇女（对照组）,回顾性分析其临床资料,检测所有受试者肝肾功能生化指标的变化情况并分析其与妊娠结局的关系.结果 三组研究对象在年龄、孕周、分娩方式方面差异均有统计学意义（P均＜ 0.05）.三组间除总胆红素和胱抑素C外,其他肝肾功能指标水平差异均有统计学意义（P均＜ 0.05）,轻度子痫前期组与对照组比较,除碱性磷酸酶（alkaline phosphatase,ALP）、尿酸（uric acid,UA）外,其余肝肾功能指标水平差异均无统计学意义（P均＞ 0.05）;重度子痫前期组与对照组比较,除直接胆红素外,其余肝肾功能指标水平差异均有统计学意义（P均＜ 0.05）;重度与轻度子痫前期组比较,除ALP、胆碱酯酶、尿素氮和UA外,其他肝肾功能指标水平差异均有统计学意义（P均＜ 0.05）.子痫前期患者分娩孕周与Apgar评分、新生儿体重呈正相关关系（r=0.754,r=0.860,P均＜0.05）.结论 子痫前期患者肝肾功能生化指标有明显改变,并严重影响妊娠的进展及胎儿的生长发育.

Change of hepatic and renal function in patients with preeclampsia and influence to fetus

Objective To explore the change of hepatic and renal function in patients with preeclampsia, and the effect of preeclampsia to the pregnancy outcome. Methods 100 patients with mild preeclampsia, 110 patients with severe preeclampsia and 100 normal late pregnancy women were collected. Clinical data were retrospectively analyzed. The hepatic and renal function indexes of all subjects were detected, and the effect of preeclampsia on the pregnancy outcome were analyzed. Results There were statistical significance in the differences of age, gestational age and delivery pattern among three groups （Pall〈 0.05）. There were statistical significance in the differences of all hepatic and renal indexes except total bilirubin and cystatin C among three groups （Pall〈 0.05）. There were no statistical significance in the differences of all hepatic and renal indexes except alkaline phosphatase（ALP） and uric acid（UA） between mild preeclampsia group and control group （Pall〉 0.05）. There were statistical significance in the differences of all hepatic and renal indexes except direct bilirubin between severe preeclampsia group and control group （Pall〈 0.05）. There were statistical significance in the differences of all hepatic and renal indexes except ALP, cholinesterase, blood urea nitrogen and UA between severe preeclampsia group and mild preeclampsia group （Pall〈 0.05）. There were positive correlation between gestational age and Apgar score, neonatus body weight （r= 0.754, r= 0.860, Pall 〈 0.05）. Conclusion The hepatic and renal function of patients with preectampsia have significant change, and show an effect on the progress of pregnancy and the growth and development of fetus.