慢性心力衰竭患者血清BNP、MMP-9、IL-6检测的临床价值

目的 通过对慢性心力衰竭（chronic heart failure,CHF）患者血清脑钠肽（brain natriureticpeptide,BNP）、基质金属蛋白酶-9（matrix metalloproteinase-9,MMP-9）及白细胞介素-6 （interleukin-6,IL-6）水平的检测,探讨其与CHF的关系.方法 选择53例CHF患者作为CHF组,20例同期健康体检者作为对照组,采用电化学发光免疫分析法测定其血清BNP的水平,酶联免疫吸附试验测定其血清MMP-9、IL-6的浓度,通过超声心动图检查,分别测定CHF组与对照组的左心室射血分数（left ventricular ejection fraction,LVEF）、左心室舒张末期内径（left ventricular end-diastolic diameter,LVEDD）、左心室收缩末期内径（left ventricular end-systolic diameter,LVESD）,并采用SPSS 19.0软件进行统计学分析.结果 CHF组患者血清BNP、MMP-9及IL-6水平显著高于对照组,差异均有统计学意义（P均＜0.05）;CHF组患者LVEDD、LVESD较对照组明显增加,LVEF较对照组明显下降,差异均有统计学意义（P均＜0.05）;CHF组患者血清BNP、MMP-9、IL-6水平与LVEDD、LVESD均呈正相关关系,而与LVEF呈负相关关系（P均＜ 0.05）.结论 血清BNP、MMP-9、IL-6水平可较好地反映出CHF患者的心脏功能状态,在CHF的发生、发展过程中起重要作用,是诊断CHF的良好指标.

The clinical value of serum BNP,MMP-9, IL-6 detection on chronic heart failure patients

Objective To investigate the relationship of chronic heart failure （CHF） with serum levels of brain natriuretic peptide （BNP）, matrix-9 （MMP-9） and Interleukin-6 （IL-6）. Methods 53 cases CHF patients （CHF group） and 20 cases healthy people （control group） were selected. Serum BNP was detected by electrochemiluminescence immunoassay. Serum MMP-9 and IL-6 were detected by enzyme-linked immunosorbent assay. Left ventricular ejection fraction （LVEF）, left ventricular end-diastolic diameter （LVEDD）, and left ventricular end-systolic diameter （LVESD） in CHF group and control group were analyzed by echocardiogram. All data were analyzed by SPSS 19.0 statistical software. Results Serum levels of BNP, MMP-9 and IL-6 in CHF group were higher than in control group, and the differences all had statistical signif- icance （Pall〈 0.05）. LYEDD and LYESD in CHF group were higher than in control group, and LVEF in CHF group was lower than in control group, and the differences all had statistical significance （Pall〈 0.05）. In CHF group, levels of BNP, MMP-9 and IL-6 had positive correlation with LVEDD and LVESD, and had negative relation with LVEF （Pall〈 0.05）. Conclusion Serum levels of BNP, MMP-9, IL-6 can reflect the CHF patients with cardiac function state better, and play an important role in the occurrence and process in CHF. They are good index to CHF diagnosis.