Investigations concerning the correlation of COX-1 inhibitory and hydroxyl radical scavenging activity |
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| Authors: | Scholz Michael Ulbrich Holger Mattern Andreas Kramb Jan-Peter Kiefer Werner Dannhardt Gerd |
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| Affiliation: | Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Johannes Gutenberg-University, Mainz, Germany. |
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| Abstract: | The aim was to study the COX-1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively. In general, the acids are more potent radical scavengers than the corresponding esters but there is no clear correlation with their COX-1 inhibiting potencies. A feasible scavenging mechanism of carboxylic acids is discussed. |
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| Keywords: | Carboxylic acids COX‐1 Hydroxyl radical scavenging SAR |
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