| 活检胃粘膜中ras、p16、p53的表达及与HP感染的关系 |
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| 引用本文： | 陈立新,杨少波,吴志强,唐晓兰.活检胃粘膜中ras、p16、p53的表达及与HP感染的关系[J].解放军医学杂志,1999,24(3):206-207. |
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| 作者姓名： | 陈立新 杨少波 吴志强 唐晓兰 |
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| 作者单位： | 100037,北京,解放军第304医院 |
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| 摘 要： | 为探讨癌相关基因与幽门螺杆菌感染在胃粘膜病变中有无相互作用关系，随机对１３６例胃镜检查的慢性浅表性胃炎，慢性萎缩性胃炎，胃溃疡，胃癌患者的胃粘知检进行了癌相关基因ｒａｓ，ｐ１６，ｐ５３及ＨＰ检测。结果显示ｒａｓ，ｐ１６ｐ５３在胃癌的阳性表达均高于胃炎和胃溃疡，经统计不处理除ｒａｓ外差异均无显著性意义，ＨＰ阳性的胃癌中，ｒａｓ和ｐ５３阳性表达均高于胃炎和胃溃疡，而ｐ１６的阳性表达则低于胃炎；
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| 关 键 词： | 胃粘膜 萎缩 化生 |
EXPRESSIONS OF ras, p16 AND p53 IN BIOPSY GASTRIC MUCOSA AND THEIR RELATIONS WI TH HELICOBACTER PYLORI INFECTION |
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| Chen Lixin,Yang Shaobo,Wu Zhiqiang et al.EXPRESSIONS OF ras, p16 AND p53 IN BIOPSY GASTRIC MUCOSA AND THEIR RELATIONS WI TH HELICOBACTER PYLORI INFECTION[J].Medical Journal of Chinese People's Liberation Army,1999,24(3):206-207. |
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| Authors: | Chen Lixin Yang Shaobo Wu Zhiqiang |
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| Institution: | Chen Lixin,Yang Shaobo,Wu Zhiqiang et al. The 304th Hospital of PLA,Beijing 100037 |
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| Abstract: | To probe the relation between oncogene and Helicobacter pylori (HP) infection in gastric mucosa lesions, ras, p16, p53 and HP were randomly determined in the mucosa biopsies of 136 patients with chronic superficial gastritis, chronic atrophic gastritis, gastric ulcer and gastric cancer diagnosed by gastroscopy. The results showed that the positive rates of ras in gastric cancer were much higher (P<0.05) than that in gastritis and gastric ulcer, and p16 lower than that in gastritis. The positive expressions of ras, p16, p53, HP, and HPpositive ras, p16 and p53 were much higher (P<0.05) than those of negative expression in chronic atrophic gastritis concomitant with intestinal metaplasia and/or a typical hyperplasia. It was suggested that oncogene and HP infection played a role in histological changes and might have an interactive relation. |
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| Keywords: | gastric mucosa atrophy metaplasia |
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