| 外力诱导培养兔成骨细胞表达c—fos的实验研究 |
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| 引用本文： | 冯雪,林珠.外力诱导培养兔成骨细胞表达c—fos的实验研究[J].实用口腔医学杂志,1999,15(2):115-117. |
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| 作者姓名： | 冯雪 林珠 |
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| 作者单位： | 第四军医大学口腔医学院，西安矿业学院 |
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| 摘 要： | 目的：探讨兔成骨细胞在机械力作用下将机械力信号转变为生物学效应的作用机理；方法：利用ＦＯＳ免疫组化技术观察在受到外力后培养的兔成骨细胞对立即早期基因ｃ－ｆｏｓ的蛋白产物（ＦＯＳ）的表达情况；结果：几乎所有的成骨细胞核均染成黄褐色，为ＦＯＳ免疫组化反应阳性；结论：ｃ－ｆｏｓ在兔成骨细胞的机械力信号向生物学效应转换的过程中可能发挥重要作用。
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| 关 键 词： | 压力 成骨细胞 原癌基因 |
The expression of c-fos in cultured rabbit osteoblasts induced by extra-force |
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| Feng Xue,Lin Zhu,Duan Yinzhong.The expression of c-fos in cultured rabbit osteoblasts induced by extra-force[J].Journal of Practical Stomatology,1999,15(2):115-117. |
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| Authors: | Feng Xue Lin Zhu Duan Yinzhong |
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| Abstract: | Objective:To investigate the role of c fos gene in the transduction of mechanical signal to biological effect in cultured rabbit osteoblasts. Method:The expression of c fos in cultured rabbit osteoblasts induced by extra force was tested by FOS protein immunocytochemical reaction.Results:Nearly all the nuclei of osteoblasts were stained dark yellow brown which showed FOS positive immunocytochemical reaction.Conclusion:The results suggeste that c fos may play an important role in the transition process of mechanical signal to biological effect in rabbit osteoblasts. |
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| Keywords: | Pressure Osteoblast Proto oncogenes |
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