| 血管性痴呆动物模型探讨 |
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| 引用本文： | 王昊,阎小萍,金笛儿.血管性痴呆动物模型探讨[J].中日友好医院学报,2005,19(2):87-89,F003. |
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| 作者姓名： | 王昊 阎小萍 金笛儿 |
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| 作者单位： | 中日友好医院,中医内科,北京,100029 |
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| 摘 要： | 目的:探讨建立小鼠"血管性痴呆"动物模型.方法:采用小鼠双侧颈总动脉反复缺血再灌注加降血压法制作了血管性痴呆动物模型.结果:跳台试验、水迷宫试验和光镜检查证实,术后模型小鼠出现了明显的学习、记忆功能障碍,形态学可见明显的小鼠海马CA1区神经细胞减少.结论:本试验成功建立了血管性痴呆动物模型,方法简便,效果可靠,利于推广.
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| 关 键 词： | 血管性痴呆 动物模型 小鼠 |
| 文章编号： | 1001-0025(2005)02-0087-03 |
Investigation on the creation of global cerebral ischemia-reperfusion injury model in mice |
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| WANG Hao,YAN Xiao-ping,JIN Di-er.Investigation on the creation of global cerebral ischemia-reperfusion injury model in mice[J].Journal of China-Japan Friendship Hospital,2005,19(2):87-89,F003. |
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| Authors: | WANG Hao YAN Xiao-ping JIN Di-er |
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| Abstract: | Objective:To establish a vascular dementia model in mice.Methods:The imitative vascular dementia model was established by repeatedly clipping the common carotid artery and reducing blood pressure with an abdominal injection of sodium nitroprusside.Results:By using step-down avoidance test and water maze test,the mice in experimental group showed a significant disfunction in learning and memory and obvious cell deletion in their hippocampal CA1 region.Conclusion:The above described method to induce vascular dementia model is effective and easily performed. |
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| Keywords: | vascular dementia model animal mice |
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