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Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease |
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| Authors: | Peter McColgan Adeel Razi Sarah Gregory Kiran K Seunarine Alexandra Durr Raymund AC Roos Blair R Leavitt Rachael I Scahill Chris A Clark Doug R Langbehn Sarah J Tabrizi Track On‐HD Investigators |
| Institution: | 1. Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom;2. Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom;3. Department of Electronic Engineering, NED University of Engineering and Technology, Karachi, Pakistan;4. Developmental Imaging and Biophysics Section, UCL Institute of Child Health, London, United Kingdom;5. APHP Department of Genetics, Groupe Hospitalier Pitié‐Salpêtrière, and Institut du Cerveau et de la Moelle, INSERM U1127, CNRS UMR7225, Sorbonne Universités – UPMC Université Paris VI UMR_S1127, Paris, France;6. Department of Neurology, Leiden University Medical Centre, The Netherlands;7. Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada;8. Department of Biostatistics, University of Iowa, Iowa City, Iowa;9. National Hospital for Neurology and Neurosurgery, Queen Square, London, United KingdomG.R. and S.J.T. contributed equally to this work. |
| Abstract: | Depression is common in premanifest Huntington's disease (preHD) and results in significant morbidity. We sought to examine how variations in structural and functional brain networks relate to depressive symptoms in premanifest HD and healthy controls. Brain networks were constructed using diffusion tractography (70 preHD and 81 controls) and resting state fMRI (92 preHD and 94 controls) data. A sub‐network associated with depression was identified in a data‐driven fashion and network‐based statistics was used to investigate which specific connections correlated with depression scores. A replication analysis was then performed using data from a separate study. Correlations between depressive symptoms with increased functional connectivity and decreased structural connectivity were seen for connections in the default mode network (DMN) and basal ganglia in preHD. This study reveals specific connections in the DMN and basal ganglia that are associated with depressive symptoms in preHD. Hum Brain Mapp 38:2819–2829, 2017. © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. |
| Keywords: | Huntington's disease brain network depression functional MRI diffusion tractography |