| 逍遥散抗慢性心理应激海马神经元凋亡的机理研究 |
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| 引用本文： | 王文竹,杨忠华,徐志伟,苏俊芳.逍遥散抗慢性心理应激海马神经元凋亡的机理研究[J].中药新药与临床药理,2011,22(3). |
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| 作者姓名： | 王文竹 杨忠华 徐志伟 苏俊芳 |
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| 作者单位： | 广州中医药大学,广州,510405 |
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| 摘 要： | 目的 观察逍遥散抗慢性心理应激海马神经元凋亡及糖皮质激素受体(GR)表达的影响.方法 Wistar 大鼠按体重分为正常组、模型组、逍遥散组.正常组及模型组灌胃等量生理盐水,逍遥散组给予逍遥散7.02g/kg.观察实验前后大鼠体重及糖水偏爱度的变化,采用PI法检测大鼠海马神经元凋亡,原位杂交法检测GR mrRNA表达.结果 经过21 d慢性轻度不可预计应激(CMUS)造模后,模型组、逍遥散组体重及增重明显低于正常组(P<0.01),模型组的糖水偏爱度明显低于正常组(P<0.01),模型组大鼠海马神经元凋亡率明显增加(P<0.05),GR mRNA表达降低(P<0.01);逍遥散可显著降低大鼠海马神经元凋亡率(P<0.05),升高GR mRNA表达(P<0.01).结论 表明CMUS可引起大鼠糖水偏爱度下降,而逍遥散能逆转CMUS抑郁大鼠的糖水偏爱度的下降,可显著改善慢性心理应激所致大鼠海马神经元凋亡,其机理可能与调节GR mRNA表达有关.
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| 关 键 词： | 心理应激 逍遥散 凋亡 糖皮质激素受体 |
Mechanism of Xiaoyao Powder in Counteracting Apoptosis of Hippocampus Neurons Caused by Chronic Psychological Stress |
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| WANG Wenzhu,YANG Zhonghua,XU Zhiwei,SU Junfang.Mechanism of Xiaoyao Powder in Counteracting Apoptosis of Hippocampus Neurons Caused by Chronic Psychological Stress[J].Traditional Chinese Drug Research & Clinical Pharmacology,2011,22(3). |
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| Authors: | WANG Wenzhu YANG Zhonghua XU Zhiwei SU Junfang |
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| Institution: | WANG Wenzhu,YANG Zhonghua,XU Zhiwei,SU Junfang(Guangzhou University of Chinese Medicine,Guangzhou 510405,China) |
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| Abstract: | Objective To investigate the effect of Xiaoyao Powder(XP) on apoptosis of hippocampus neurons and glucocorticoid receptor(GR) mRNA expression caused by chronic psychological stress.Methods Wistar rats were randomized to 3 groups: normal group(without any stimulation,gastric gavage of 2 mL normal saline per day),model group(chronic mild unpredictable stress,gastric gavage of 2 mL normal saline per day) and XP group(gastric gavage of 2 mL XP one hour before stress).The changes of body weight and sucrose prefe... |
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| Keywords: | Psychological stress Xiaoyao Powder Apoptosis Glucocorticoid receptor |
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