| 二甲双胍对多囊卵巢综合征患者卵巢形态的影响 |
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| 引用本文： | 易清华,凌晟荣,黄晓燕,易村犍. 二甲双胍对多囊卵巢综合征患者卵巢形态的影响[J]. 职业与健康, 2011, 27(8): 949-951 |
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| 作者姓名： | 易清华 凌晟荣 黄晓燕 易村犍 |
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| 作者单位： | 长江大学附属第一医院,湖北省荆州市第一人民医院,妇产科,434000 |
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| 摘 要： | 目的探讨对二甲双胍具有不同排卵反应的多囊性卵巢综合征（PCOS）患者的卵巢形态学变化。方法年轻、体重指数正常的PCOS患者接受6个月二甲双胍治疗中,选取20例治疗后仍无排卵者为无排卵组,20例有排卵但是未能成功妊娠者为排卵组。另选取20例年龄和体重指数与无排卵组、排卵组匹配的PCOS患者（未做任何治疗）作为对照组。检测3组患者的睾酮（T）、性激素结合球蛋白（SHBG）、卵泡刺激素（FSH）、黄体生成素（LH）、雌激素（E2）、催乳素（PRL）、空腹血糖、空腹胰岛素、动态平衡模型分析胰岛素抵抗指数（HOMA）、空腹血糖-胰岛素比值（G IR）,B超观察卵巢形态、体积的变化。结果二甲双胍治疗6个月后,无排卵组有3例（15%）、排卵组有17例（85%）出现卵巢形态学改变,对照组无一例出现卵巢形态变化。与治疗前比较,无排卵组治疗6个月后卵巢体积无明显变化[（12.2±1.2）cm3],而排卵组则明显下降[（11.5±1.6）cm3]。结论 PCOS患者使用二甲双胍治疗后可出现与排卵反应密切相关的卵巢形态学改变。
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| 关 键 词： | 多囊卵巢综合征 二甲双胍 卵巢 |
Effect of Metformin on Ovarian Morphology of Patients with Polycystic Ovary Syndrome |
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| YI Qing-hua,LING Sheng-rong,HUANG Xiao-yan,YI Cun-jian. Effect of Metformin on Ovarian Morphology of Patients with Polycystic Ovary Syndrome[J]. Occupation and Health, 2011, 27(8): 949-951 |
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| Authors: | YI Qing-hua LING Sheng-rong HUANG Xiao-yan YI Cun-jian |
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| Affiliation: | YI Qing-hua,LING Sheng-rong,HUANG Xiao-yan,YI Cun-juan(Department of Gynecology and Obstetrics,the First Hospital Affiliated to Yangtz University(the First People's Hospital of Jingzhou),Hubei,434000,China) |
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| Abstract: | [Objective]To investigate the effect of metformin on the changes of ovarian morphology in patients with polycystic ovary syndrome(PCOS).[Methods]Yong and of normal body mass index patients with PCOS were administered to receive metformin treatment for 6 months.20 patients remained anovulatory(anovulatory group),while 20 patients became ovulatory but failed to conceive(ovulatory group).Another 20 age and body mass index matched patients with PCOS were included as control group.The concentrations of androgen(... |
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| Keywords: | Polycystic ovary syndrome Metformin Ovary |
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