| 平喘汤对支气管哮喘大鼠肺组织IgE、TGF β1及TNF-α的影响 |
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| 引用本文： | 冯高华,朱虹,孙峰,贾永良.平喘汤对支气管哮喘大鼠肺组织IgE、TGF β1及TNF-α的影响[J].中药新药与临床药理,2011,22(3). |
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| 作者姓名： | 冯高华 朱虹 孙峰 贾永良 |
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| 作者单位： | 1. 扬州大学医学院,江苏扬州,225001;张家港市中医院,江苏张家港,215600
2. 扬州大学医学院,江苏扬州,225001 |
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| 摘 要： | 目的 探讨平喘汤对支气管哮喘大鼠的干预作用.方法 将SD大鼠48只随机分为正常对照组、哮喘模型组、平喘汤低剂量组、平喘汤中剂量组、平喘汤高剂量组、阳性药物(博利康尼)对照组.采用卵蛋白致敏复制大鼠支气管哮喘模型,治疗组从实验开始第3周起,平喘汤高、中、低剂量组以2.6 mL/次、1.3 mL/次、0.7 mL/次剂量灌胃,阳性药物(博利康尼)对照组0.1 mL/次剂量灌胃,正常组及模型组均给予1.3 mL/次生理盐水灌胃,每天一次,连续4周.观察大鼠一般情况,大鼠肺组织IgE、TGF β1及TNF-α的变化.结果 哮喘组及各治疗组大鼠肺组织IgE、TGF β1及TNF-α含量均高于正常组,差异显著(P<0.05);各治疗组大鼠肺组织IgE、TGF β1及TNF-α含量均低于哮喘组,有显著性差异(P<0.05);与博利康尼组相比,平喘汤高剂量组大鼠肺组织IgE、TNF-α含量显著降低(P<0.01),而TGFβ1含量无统计学差异(P>0.05);平喘汤中剂量组大鼠肺组织IgE、TGFβ1含量高于博利康尼组(P<0.05),而TNF-α含量无统计学差异(P>0.05);平喘汤低剂量组大鼠肺组织IgE、TGFβ1、TNF-α含量均高于博利康尼组(P<0.01).平喘汤高剂量组优于低剂量组.结论 平喘汤能够通过下调大鼠肺组织IgE、TGFβ1及TNF-α含量,可降低气道高反应性、减轻气道炎症症状、控制或延缓气道纤维化进程.
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| 关 键 词： | 支气管哮喘 气道高反应性 转化生长因子β1 肿瘤坏死因子α |
Effect of Pingchuan Decoction on IgE, Transforming Growth Factor-beta 1 and Tumor Necrosis Factor-alpha in Lung Tissues of Rats with Bronchial Asthma |
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| FENG Gaohua,ZHU Hong,SUN Feng,JIA Yongliang.Effect of Pingchuan Decoction on IgE, Transforming Growth Factor-beta 1 and Tumor Necrosis Factor-alpha in Lung Tissues of Rats with Bronchial Asthma[J].Traditional Chinese Drug Research & Clinical Pharmacology,2011,22(3). |
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| Authors: | FENG Gaohua ZHU Hong SUN Feng JIA Yongliang |
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| Institution: | FENG Gaohua1,2,ZHU Hong1,SUN Feng1,JIA Yongliang1(1.Medical college of Yangzhou University,Yangzhou 225001 Jiangsu,China,2.Zhangjiagang Hospital of TCM,Zhangjiagang 215600 Jiangsu,China) |
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| Abstract: | Objective To investigate the therapeutic effect of Pingchuan Decoction(PD) on rats with bronchial asthma.Methods Forty-eight SD rats were randomly divided into six groups: the normal group,the model group,low-dose PD(0.7 mL,once a day) group,medium-dose PD group(1.3 mL once a day),high-dose PD group(2.6 mL once a day),and positive medicine(Terbutaline Sulphate Tablets,0.1mL once a day) group.Except for the normal group,all rats in other groups were given intraperitoneal injection of ovalbumin(OVA) and force... |
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| Keywords: | IgE |
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