Effect of <Emphasis Type="Italic">Gastrodia elata</Emphasis> on tumor necrosis factor-alpha-induced matrix metalloproteinase activity in endothelial cells |
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| Authors: | Yun Jung Lee Sun Mi Hwang Dae Gill Kang Jin Sook Kim Ho Sub Lee |
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| Institution: | (1) Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, 570-749, Republic of Korea;(2) Medical Resources Research Institute (MeRRI), Wonkwang University, Iksan, Chonbuk, 570-749, Republic of Korea;(3) Korea Institute of Oriental Medicine, Jeonmin-dong, Yusung-gu, Daejeon, 305-811, Republic of Korea; |
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| Abstract: | The aim of the present study was to investigate whether an ethanol extract of Gastrodia elata (EGE) rhizome, a traditional Korean herbal medical food, suppresses the endothelial extracellular matrix degradation induced
by tumor necrosis factor (TNF)-α. Gelatin zymography results showed that pretreatment with EGE to human umbilical vein endothelial
cells (HUVEC) decreased TNF-α-induced increase of matrix metalloproteinase (MMP)-2/-9 activities in the range of 1–50 μg/ml.
Real-time qRT-PCR results also revealed that TNF-α-induced MMP-2/-9 mRNA expression levels were attenuated by pretreatment
with EGE. These results provide new insights into the pathophysiological mechanisms for the anti-atherosclerotic properties
of EGE in vascular diseases. |
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