| 摘 要： | Anisodine(AT_3)is a new alkaloid isolatedfrom Scopolia tangutica,Anisodus tanguticus,a plant of Solauaeeae family,collected fromMt.Tanggute.AT_3 has anticholinergic property.The influences of AT_3 on memory behavior,hip-pocampal electrical activity and acetylcholinecontent in animals were studied.The evalua-tion of memory deficits was based on the fol-lowing:(1)percentage of conditioned passiveavoidance reaction(CAR),(2)mean responsetime,(3)mean ability to perform correctly 5successive times in 10 trials,(4)mean numberof trials to correctly perform 9 out of 10 trials.It was found that AT_3 influences unconsolidatedmemory(three day training period)more thanconsolided memory(six day training period).It was also observed that the nmemonia effectsof AT_3 was associated with ECoG changes andcholinergic reduction in hippocampus.The majorfindings arising from studies of hippocampalelectrical activity in orienting experiments isthat hippocampal electrical response decreasedafter AT_3 injection.These findings suggestedthat the chronic administration of AT_3 raises thepossibility of impairing the ability of patients,particularly elderly ones,to learn new materialand to store,or acquire new information intolong-term memory.
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