清香藤化学成分的分离与鉴定

目的对中药清香藤(Jasminum lanceolarium Roxb.)的化学成分进行分离与鉴定。方法采用反复硅胶柱色谱、Sephadex LH-20、重结晶等方法进行分离纯化,通过理化常数测定和光谱分析鉴定其化学结构。结果从清香藤提取物的乙酸乙酯层中分离得到了8个化合物,即腺嘌呤核苷(a-denosine,1)、咖啡酸(caffeic acid,2)、反式对香豆酸(E-p-coumatic acid,3)、白桦脂酸(betulinicacid,4)、松脂素((+)-pinoresinol,5)、Erythro-1-(4-hydroxy-3-methoxyphenyl)-2-{4-(E)-3-hy-droxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol(6)、threo-1-(4-hydroxy-3-methoxyphenyl)-2-{4-(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol(7)、jasminlan A(8)。结论化合物1、2、5、6、7为首次从清香藤植物中分离得到。

Chemical constituents from the Jasminum lanceolarium Roxb.

Objective To isolate the constituents of Jasminum lanceolarium Roxb.and identify their structures.Methods The compounds were isolated by chromatography on silica gel column Sephadex LH-20, and identified on the basis of physico-chemical constants and spectral analysis. Results Eight compounds were identified as adenosine (1), caffeic acid (2), E-p-coumatic acid (3), betulinic acid (4), (+)-pinoresinol (5), Erythro-1-(4-hydroxy-3-methoxyphenyl)-2-{4-(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol（6）, threo-1- (4-hydroxy-3-methoxyphenyl)-2-{4-(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol（7）, jasminlan A（8）.Conclusion Compounds 1, 2, 5, 6 and 7 are isolated from Jasminum lanceolarium Roxb for the first time.