| 枸杞多糖对人肺癌A549细胞影响的研究 |
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| 引用本文： | 肖琳,白秀珍,杨学东. 枸杞多糖对人肺癌A549细胞影响的研究[J]. 数理医药学杂志, 2006, 19(2): 130-132 |
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| 作者姓名： | 肖琳 白秀珍 杨学东 |
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| 作者单位： | 锦州医学院生物化学与分子生物学教研室,锦州,121001;锦州医学院生物化学与分子生物学教研室,锦州,121001;锦州医学院生物化学与分子生物学教研室,锦州,121001 |
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| 摘 要： | 目的:探讨枸杞多糖(LBP)对人肺癌A549细胞的影响及作用机制。方法:将LBP作用于肺癌A549细胞,应用M TT法、电镜和钙离子测定等技术测定LBP的抗肿瘤作用及作用机理。结果:LBP呈剂量依赖性(100m g/L~2000m g/L)地抑制人肺癌A549细胞的增殖,诱导其凋亡,并可使细胞内钙离子浓度升高。结论:LBP可诱导A549细胞凋亡,其作用机制可能与细胞内钙离子浓度升高有关。
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| 关 键 词： | 枸杞多糖 细胞凋亡 人肺癌A549细胞 钙离子 |
| 文章编号： | 1004-4337（2006）02-0130-03 |
| 收稿时间： | 2005-07-07 |
| 修稿时间： | 2005-07-07 |
Effect of Flycium Barbarum Polysaccharide on Apotosis of Human Lung Cancer Cells |
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| Xiao Lin, et al. Effect of Flycium Barbarum Polysaccharide on Apotosis of Human Lung Cancer Cells[J]. Journal of Mathematical Medicine, 2006, 19(2): 130-132 |
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| Authors: | Xiao Lin et al |
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| Affiliation: | Jinzhou Medical College, Jingzhou 121001 |
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| Abstract: | Objective: To investigate the effect and mechanism of LBP on Apotosis of Human Lung Cancer Cells.Methods: Cells was incubated with LBP.The effect was detected by MTT,electronic microscope and level of intracellular free calcium concentration.Results: LBP inhibited the growth of A_(549) cells in dose-dependent manner and induced the apoptosis of them.And the level of intracellular free calcium concentration in the A_(549) cells was significantly higher than that of the control group.Conclusion: LBP can induce the apoptosis of A_(549) cells,and one of its molecular mechanism may be associated with the rising of the level of intracellular free calcium concentration. |
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| Keywords: | flycium barbarum polysaccharide apoptosis human Lung dancer A_(549) cells Ca~(2 ) |
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