Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia |
| |
| Authors: | N X von der Weid H de Crousaz D Beck T Deonna J Miklossy R C Janzer |
| |
| Affiliation: | Pediatric Department, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. |
| |
| Abstract: | We report a case of a fatal toxic encephalomyelopathy in a 12-year-old girl due to prophylactic intrathecal injection of methotrexate and cytosine arabinoside, with a characteristic progressive symptomatology leading to death after 28 days. The location and type of neuropathological changes support the hypothesis of a direct toxic effect of methotrexate and/or cytosine arabinoside on structures directly exposed to the cerebrospinal fluid. |
| |
| Keywords: | |
|
|
