| 药物筛选技术的最新进展--高内涵筛选 |
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| 引用本文： | 孙婉,李敏.药物筛选技术的最新进展--高内涵筛选[J].中国新药杂志,2006,15(1):12-16. |
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| 作者姓名： | 孙婉 李敏 |
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| 作者单位： | 北京大学天然药物及仿生药物国家重点实验室,北京,100083 |
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| 摘 要： | 化合物活性筛选是创新药物研究过程的起点和具有决定意义的关键步骤。基于细胞的高内涵药物筛选技术实现了对化合物多靶点多参数的同时检测，代表着创新药物研究技术发展的必然趋势，将在未来的新药研发过程中发挥重要作用。笔者介绍了高内涵筛选技术的概念、系统组成，分析了其优势特点，并简要讨论了其在新药研究尤其是抗肿瘤药物研究中的实际应用。
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| 关 键 词： | 药物筛选 创新药物 高内涵筛选 活性化合物 |
| 文章编号： | 1003-3734（2006）01-0012-05 |
| 收稿时间： | 2005-06-30 |
| 修稿时间： | 2005年6月30日 |
A novel advancement in drug screening techniques: high content screening |
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| SUN Wan,LI Min.A novel advancement in drug screening techniques: high content screening[J].Chinese Journal of New Drugs,2006,15(1):12-16. |
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| Authors: | SUN Wan LI Min |
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| Institution: | State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100083, China |
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| Abstract: | Benefits of the screening bioactive compounds are crucial for innovation of pharmaceutical agents in different stages of drug development. High content screening (HCS) technology is the core-screening platform of a cellular analysis meeting demands in different areas of drug development such as research, assays development or toxicity screening. One of the crucial advantages is the great flexibility allowing analysis of multi-tissue sections, cytological samples and micro-plates on the same adapted instrument, matching criteria of accuracy, reliability and laboratory productivity. This presentation discussed the concept, components and advantages of the HCS as well as the applications in the research of anticancer drug development. |
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| Keywords: | drug screening innovative drug high content screening bioactive compound |
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