Effects of delta sleep-inducing peptide on pre-and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats |
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Authors: | V. V. Grigor’ev T. A. Ivanova E. A. Kustova L. N. Petrova T. P. Serkova S. O. Bachurin |
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Affiliation: | (1) Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka |
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Abstract: | We studied the effect of delta sleep-inducing peptide on GABA receptors of hippocampal and cerebellar neurons in rats. It was shown that delta sleep-inducing peptide considerably and dose-dependently potentiates GABA-activated currents in these neurons and blocks NMDA-activated potentiation in cortical and hippocampal neurons. The peptide modulates activity of presynaptic NMDA receptors, which is seen from changes in 45Ca2+ uptake into synaptosomes of the brain cortex after uptake stimulation with glutamate and NMDA. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 8, pp. 149–151, August, 2006 |
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Keywords: | delta sleep-inducing peptide GABA receptors NMDA receptors 45Ca2+ uptake into synaptosomes |
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