New perspectives on schizotypal personality disorder |
| |
Authors: | Richelle M Kirrane MB MRCPsych Larry J Siever MD |
| |
Institution: | (1) Psychiatry Service 116A, Bronx Veterans Affairs Medical Center, 130 West Kingsbridge Road, 10468 Bronx, NY, USA |
| |
Abstract: | Schizotypal personality disorder is the prototype of the schizophrenia-related personality disorders and has been demonstrated
to have phenomenologic, biologic, treatment, and outcome characteristics similar to those of schizophrenic patients. These
studies suggest that patients with schizotypal personality disorder, like schizophrenic patients, show cognitive impairment,
but the impairment is more focal and involves primarily working memory, verbal learning, and sustained attention rather than
generalized intellectual deficits. Schizotypal patients, like schizophrenic patients show reductions in temporal lobe volume,
but seem to be spared the frontal volume reductions found in some studies of schizophrenic patients and in our laboratory.
Better frontal “buffering” may prevent the more severe cognitive and social deterioration associated with schizophrenia. Furthermore,
schizotypal patients appear to show less susceptibility to psychotic symptoms, in part perhaps because of better buffered
subcortical dopaminergic activity as suggested by recent data from a SPECT/amphetamine paradigm, glucose metabolic study,
and structural studies of basal ganglia. These findings are discussed in terms of a model of schizotypal personality disorder
where schizotypal patients have better capacity for compensatory buffering in lateral and subcortical brain regions, protecting
them from the more severe symptoms of chronic schizophrenia. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|