| 成人急性髓性白血病的反常免疫表型 |
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| 引用本文： | 陈珊珊,张海帆,薛文韬,李鲲,傅剑峰,吴平娜,王德炳.成人急性髓性白血病的反常免疫表型[J].中国实验血液学杂志,1993(1). |
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| 作者姓名： | 陈珊珊 张海帆 薛文韬 李鲲 傅剑峰 吴平娜 王德炳 |
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| 作者单位： | 北京医科大学血液病研究所，北京医科大学血液病研究所，北京医科大学血液病研究所，北京医科大学血液病研究所，北京医科大学血液病研究所，北京医科大学血液病研究所，北京医科大学血液病研究所 北京 100034，北京 100034，北京 100034，北京 100034，北京 100034，北京 100034，北京 100034 |
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| 摘 要： | 对58例未经治疗的成人AML骨髓细胞用FCM及13种MoAB进行免疫表型测定。53.4%患者骨髓单个核细胞呈现纯髓系抗原表达(Ly~-AML)。34.5%患者的骨髓细胞除髓系外伴有淋巴系抗原表达(Ly~+AML)。在Ly~+FKAML,其淋巴系抗原表达的荧光强度明显弱于其髓系抗原的。在同样的诱导缓解治疗方案下,Ly~+AML组达完全缓解天数明显长于Ly~-AML组。AML细胞这种免疫表型特点是监测残存白血病细胞的良好标志,亦对临床提示应采用相应的治疗方案。
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| 关 键 词： | 急性髓性白血病 流式细胞仪 单克隆抗体 |
ABERRATION OF ANTIGEN EXPRESSION IN ADULT ACUTE MYELOCYTIC LEUKEMIAS |
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| Shan-Shan Chen Hai-Fan Zhang Wen-Tao Xue Kun Li,Jian-Feng Fu Ping-Na Wu De-Bing Wang.ABERRATION OF ANTIGEN EXPRESSION IN ADULT ACUTE MYELOCYTIC LEUKEMIAS[J].Journal of Experimental Hematology,1993(1). |
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| Authors: | Shan-Shan Chen Hai-Fan Zhang Wen-Tao Xue Kun Li Jian-Feng Fu Ping-Na Wu De-Bing Wang |
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| Abstract: | Marrows from 58 cases of newly diagnosed acute myelocytic leukemia(FAB-AML) were immunophenotyped by flow cytometry with 13 kinds of monoclonal antibodies. 53.4% of patients marrows showed pure myeloid antigen expression (Ly AML) and 34.5%displayed both myeloid and lymphocyte associated antigen expression (Ly+AML). In genenal, fluorescence intensity of lymphocyte associated antigen in Ly+AML was weaker than that of the myeloid antigen. Cells with myeloid and lymphoid marker distributed randomly in DNA-aneuploidy and diploidy. Days to reach the first complete remission were longer in Ly+AML. The aberration antigen expression in AML allows a sensitive detection of minimal residual leukemic cells in complete remissive bone marrow and directs the treatment protocal. |
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| Keywords: | acute myelocytic leukemia flow cytometry monoclonal antibody |
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