| 中药川贝对哮喘模型小鼠肺水肿和支气管炎症的影响 |
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| 引用本文： | 李厚忠,;任公平,;张羽飞.中药川贝对哮喘模型小鼠肺水肿和支气管炎症的影响[J].中医药信息,2014(6):19-22. |
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| 作者姓名： | 李厚忠 ;任公平 ;张羽飞 |
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| 作者单位： | [1]牡丹江医学院,黑龙江牡丹江157011; [2]牡丹江医学院红旗医院,黑龙江牡丹江157011; [3]牡丹江医学院医药研究中心,黑龙江牡丹江157011 |
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| 基金项目： | 牡丹江医学院科学技术研究项目（No.2010-34） |
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| 摘 要： | 目的：确定中药川贝对哮喘模型小鼠肺水肿和支气管炎症的影响.方法：建立哮喘小鼠模型并随机分为模型组（OVA致敏的小鼠）,中药川贝组（中药川贝治疗的小鼠）和PBS组（正常对照组的小鼠）.结果：中药川贝可抑制哮喘模型小鼠肺水肿,降低BALFIL-1和IL-6水平,同时还可降低亚硝酸盐浓度和减轻中性粒细胞的浸润,并且使哮喘模型小鼠血清IgE水平降低.结论：中药川贝通过抑制哮喘模型小鼠血清IgE水平可减轻肺水肿及支气管中性粒细胞炎症.
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| 关 键 词： | 哮喘 肺水肿 IL-1 IL-6 IgE |
Effect of Bulbus Fritillariae Cirrhosae on Pulmonary Edema and Bronchial Neutrophilic Inflammation of Asthma Model Mice |
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| Institution: | LI Hou-zhong,REN Gong-ping,ZHANG Yu-fei( 1.Mudanjiang Medical University, Mudanjiang 157011, China; 2.Hongqi Hospital Affiliated to Mudanjiang Medical University,Mudanjiang 157011, China; 3.Medical Research Center, Mudanjiang Medical University, Mudanjiang 157011, China;) |
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| Abstract: | Objective：To investigate the effect of Bulbus Fritillariae Cirrhosae on pulmonary inflammation in allergic asthma model mice.Methods：Murine asthma models were established and mice were divided into a model group （OVA-sensitized and challenged mice）,a BFC group （Bulbus Fritillariae Cirrhosae for mice） and a PBS group （normal control mice）.Results：Bulbus Fritillariae Cirrhosae inhibited pulmonary edema and decreased interleukin （IL）-1 and IL-6 levels in bronchoalveolar lavage fluid in OVA-treated mice.Bulbus Fritillariae Cirrhosae also decreased pulmonary nitrite level and neutrophil infiltration induced by OVA.Moreover,Bulbus Fritillariae Cirrhosae decreased serum IgE level in OVA-treated mice.Conclusion：Bulbus Fritillariae Cirrhosae may attenuate pulmonary edema and bronchial neutrophilic inflammation by inhibiting systemic IgE level in allergic asthma. |
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| Keywords: | Asthma Pulmonary edema IL-1 IL-6 IgE |
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