香菇多糖胸腔灌注联合全身化疗治疗晚期非小细胞肺癌伴恶性胸腔积液临床观察

目的观察香菇多糖胸腔灌注联合全身化疗治疗晚期非小细胞肺癌伴恶性胸腔积液的临床疗效。方法将80例晚期非小细胞肺癌伴恶性胸腔积液的患者随机分为观察组和对照组各40例。观察组采用香菇多糖胸腔灌注联合全身化疗治疗,对照组采用单纯胸腔穿刺置管引流加全身化疗。观察患者治疗后瘤体疗效、胸水、生活质量、毒副反应。结果两组瘤体疗效有效率分别为32.5%、30.0%,差异无统计学意义（P〉0.05）;胸水疗效比较,观察组总有效率为87.5%,优于对照组的60.0%（P〈0.05）;提高生活质量方面,观察组改善率为45.0%,优于对照组的35.0%（P〈0.05）;毒副反应方面,胸痛和胃肠道反应发生率观察组低于对照组（P〈0.05）。结论香菇多糖胸腔灌注联合全身化疗在控制晚期非小细胞肺癌伴恶性胸腔积液方面疗效确切,且能减轻化疗药物的毒副作用、提高患者的生活质量。

Clinical Observation of Lentinan Cavity Injection Combined with Chemotherapy on Non-small Cell Lung Cancer with Malignant Pleural Effusion

Objective To observe the clinical effects of lentinan cavity injection combined with systemic chemotherapy on treating non-small cell lung cancer merged with malignant pleural effusion. Methods 80 cases of advanced non-small cell lung cancer patients were randomly divided into observation group（n =40） and control group（n =40）. The observation group was applied with lentinan cavity injection combined with chemotherapy. The control group was treated with only chest tube drainage plus chemotherapy. The tumor clinical curative effects, pleural effusion, quality of life,toxic and side effect in patients were observed. Results The effective rates in both groups were32.5% and 30.0%, there were no significant differences（P〉0.05）. The pleural effusion efficacy in the observation group was 87.5%, which was superior to that the 60.0% of control group（P〈0.05）.The quality of life improving rate in observation group was 45%, which was better than that35.0% in the control group（P〈0.05）. The chest pain and gastrointestinal reaction on toxic and side effect were less observed in observation group than that in control group（P〈0.05）.Conclusion Lentinan cavity injection combined with systemic chemotherapy on treating non-small cell lung cancer merged with malignant pleural effusion exhibited definite effects. Moreover, it could reduce the side effects of chemotherapeutics, improve the quality life for patients.