结构蛋白Gag及其相关基因 (蛋白) 在HIV-1晚期复制的作用及其抑制剂

人免疫缺陷病毒1型 (human immunodeficiency virus type 1, HIV-1) 复制的晚期阶段是整个复制周期中的关键环节。该阶段HIV-1经装配、出芽释放和成熟过程产生能感染新靶细胞的成熟病毒颗粒。结构蛋白Gag及其相关基因 (蛋白) 在此阶段发挥着重要作用, 它通过协同自身不同区域, 有利于蛋白质-蛋白质、蛋白质- RNA和蛋白质-脂质相互作用, 从而促进成熟感染病毒颗粒的产生。针对此阶段设计的药物, 可有效地阻断HIV-1成熟, 从而抑制病毒感染。本文综述了结构蛋白Gag及其相关基因 (蛋白) 在HIV-1晚期复制的作用及其抑制剂的研究进展。

The role of structural protein Gag and related gene (protein) in late stages of the HIV-1 replication cycle and the inhibitors

The late stages of the HIV-1 replication cycle are important to the overall replication cycle.  During the late stages, HIV-1 replication undergoes the processes of assembly, release, and maturation, resulting in the production of a mature virus particle capable of infecting a new target cell.  The structural protein Gag and its related gene (protein) play a central role in these pathways.  The different regions of Gag worked in   concert to drive production of a mature infectious particle through protein-protein, protein-RNA and protein-lipid interactions.  The designed drug aimed directly at these stages can efficiently block the maturation and infectivity of HIV-1.  In this article, the role of structural protein Gag and related gene (protein) in late stages of the HIV-1 replication cycle and related inhibitors is reviewed.