| 硝苯地平乳膏剂的制备与质量控制 |
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| 引用本文： | 李菲,杨艳霞,郭丰广,郝吉福,孔志峰,宋涛.硝苯地平乳膏剂的制备与质量控制[J].泰山医学院学报,2007,28(2):90-92. |
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| 作者姓名： | 李菲 杨艳霞 郭丰广 郝吉福 孔志峰 宋涛 |
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| 作者单位： | 1. 泰山医学院药学院,山东,泰安,271016
2. 泰山医学院04级药学专升本,山东,泰安,271016 |
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| 摘 要： | 目的研制硝苯地平乳膏,并建立质量控制的方法。方法拟定三种不同处方与制备工艺,以基质的稳定性及外观性状为考察指标,采用综合评分法对基质处方和制备工艺进行筛选。制备硝苯地平乳膏,并考察其稳定性,用差示分光光度法测定含量。结果制备的硝苯地平乳膏外观性状良好,质量稳定,药物含量为84.29%,平均回收率100.69%。结论该乳膏剂处方合理,制备方法可行。
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| 关 键 词： | 硝苯地平 乳膏剂 制备 质量控制 |
| 文章编号： | 1004-7115（2007）02-0090-03 |
| 收稿时间： | 2006-12-12 |
| 修稿时间： | 2006年12月12 |
Preparation and quality control of Nifedipine cream |
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| LI Fei,YANG Yan-xia,GUO Feng-guang,HAO Ji-fu,KONG Zhi-feng,SONG Tao.Preparation and quality control of Nifedipine cream[J].Journal of Taishan Medical College,2007,28(2):90-92. |
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| Authors: | LI Fei YANG Yan-xia GUO Feng-guang HAO Ji-fu KONG Zhi-feng SONG Tao |
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| Abstract: | Objective:To prepare Nifedipinecream and establish its standard of quality control.Methods: The content of Nifedipine in preparation was determined by the UV spectrophotometric method and its stability tests were carried out.Results: The content of Nifedipine in preparation was 84.29% and the recovery of the assay was 100.69%.Conclusion: The formula was reasonable,and the preparation method was feasible. |
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| Keywords: | nifedipine cream preparation quality control |
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