| 环氧合酶-2抑制剂对口腔鳞癌血管生成的影响 |
| |
| 引用本文： | 孙晓菊,谢洪,王绪凯,张辉,宋丛笑,张玉杰.环氧合酶-2抑制剂对口腔鳞癌血管生成的影响[J].上海口腔医学,2012,21(4):366-369. |
| |
| 作者姓名： | 孙晓菊 谢洪 王绪凯 张辉 宋丛笑 张玉杰 |
| |
| 作者单位： | 1. 辽宁省人民医院口腔科,辽宁沈阳,110016
2. 中国医科大学口腔医学院,辽宁沈阳,110002 |
| |
| 摘 要： | 目的:探讨环氧合酶-2抑制剂对口腔鳞癌发生过程中血管生成的影响。方法:选取人舌鳞癌细胞株Tca8113作为实验样本。应用反转录聚合酶链反应(PT-PCR)及Western印迹方法检测在COX-2抑制剂NS-398对Tca8113细胞系表达VEGF、Survivin的mRNA及蛋白水平的影响。采用SPSS11.5软件包对数据进行统计学分析。结果:NS-398可下调Tca8113细胞系VEGF及Survivin的表达,且表现出一定的时间依赖性。结论:COX-2抑制剂NS-398可降低口腔鳞状癌细胞Tca8113 VEGF及Survivin的mRNA及蛋白质含量的水平,在口腔鳞癌血管形成及基因凋亡过程中起着重要作用。
|
| 关 键 词： | 口腔鳞癌 Tea8113 COX-2 VEGF Survivin |
The influence of COX-2 depressant in angiogenesis of oral squamous cell carcinoma |
| |
| SUN Xiao-ju
,
XIE Hong
,
WANG Xu-kai
,
ZHANG Hui
,
SONG Cong-xiao
,
ZHANG Yu-jie.The influence of COX-2 depressant in angiogenesis of oral squamous cell carcinoma[J].Shanghai Journal of Stomatology,2012,21(4):366-369. |
| |
| Authors: | SUN Xiao-ju XIE Hong WANG Xu-kai ZHANG Hui SONG Cong-xiao ZHANG Yu-jie |
| |
| Institution: | 1.(1.Department of Stomatology,Liaoning Provincial People’s Hospital.Shenyang 110016;2.School of Stomatology,China Medical University.Shenyang 110002,Liaoning Province,China) |
| |
| Abstract: | PURPOSE: To investigate the COX-2 depressant on cell apoptosis and angiogenesis of oral squamous cell carcinoma.METHODS: RT-PCR and Western blotting were used to detect the effect of NS-398,the COX-2 inhibitor on mRNA and protein expression of VEGF and Survivin in oral squamous carcinoma cell line Tca8113.SPSS11.5 software package was used for statistical analysis.RESULTS: NS-398 could down-regulate the expression of VEGF and Survivin in Tca8113 in a time-dependent manner.CONCLUSIONS: NS-398 could down-regulate the expression of VEGF and survivin in Tca8113 and plays an important role in cell apoptosis and angiogenesis of oral squamous cell carcinoma. |
| |
| Keywords: | Oral squamous cell carcinoma Tca8113 COX-2 VEGF Survivin |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
